DNASE1L3 and IMPDH2

		DNASE1L3	IMPDH2
Description		deoxyribonuclease 1L3	inosine monophosphate dehydrogenase 2
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GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Calcium Ion Binding Protein Binding Hydrolase Activity	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Programmed Cell Death Involved In Cell Development Programmed Cell Death Regulation Of Neutrophil Mediated Cytotoxicity	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process
Pathways			Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Eating disorders (purging via substances) ( 23568457) Height ( 28552196) Limited cutaneous systemic scleroderma ( 24387989) Rheumatoid arthritis ( 23143596 24390342 30423114 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic sclerosis ( 24387989 28314753 30572963 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: CYSRT1 KRTAP5-9	17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		1776	3615
HPRD ID		03764	00895
Ensembl ID		ENSG00000163687	ENSG00000178035
Uniprot IDs		Q13609	A0A7I2YQK5 E7ETK5 H0Y4R1 P12268
PDB IDs		7KIU	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?		IMP Dehydrogenase Activity Epidermis Development GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Interleukin-4 GTP Metabolic Process GMP Metabolic Process Cellular Response To Interleukin-4 Tissue Development Nucleoside Monophosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Biological Process Involved In Interaction With Symbiont Skin Epidermis Development Establishment Of Skin Barrier Cornified Envelope Peroxisomal Membrane	Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process
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