DNASE1L3

Description		deoxyribonuclease 1L3
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GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum
	Molecular Function	DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Calcium Ion Binding Protein Binding Hydrolase Activity
	Biological Process	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Programmed Cell Death Involved In Cell Development Programmed Cell Death Regulation Of Neutrophil Mediated Cytotoxicity
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Eating disorders (purging via substances) ( 23568457) Height ( 28552196) Limited cutaneous systemic scleroderma ( 24387989) Rheumatoid arthritis ( 23143596 24390342 30423114 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic sclerosis ( 24387989 28314753 30572963 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Novel Interacting Genes		1 novel interacting genes: IMPDH2
Interacting Genes		2 interacting genes: CYSRT1 KRTAP5-9
Entrez ID		1776
HPRD ID		03764
Ensembl ID		ENSG00000163687
Uniprot IDs		Q13609
PDB IDs		7KIU
Enriched GO Terms of Interacting Partners?		IMP Dehydrogenase Activity Epidermis Development GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process GMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Interleukin-4 GTP Metabolic Process GMP Metabolic Process Cellular Response To Interleukin-4 Tissue Development Nucleoside Monophosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Biological Process Involved In Interaction With Symbiont Skin Epidermis Development Establishment Of Skin Barrier Cornified Envelope Peroxisomal Membrane
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