DNAH9 and NLGN2

		DNAH9	NLGN2
Description		dynein axonemal heavy chain 9	neuroligin 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Dynein Complex Motile Cilium Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Distal Portion Of Axoneme	Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Dendritic Shaft Synapse Postsynaptic Membrane Excitatory Synapse Inhibitory Synapse Ribbon Synapse Glycinergic Synapse Dopaminergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Postsynaptic Specialization Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Cilium Movement Microtubule-based Movement Cell Projection Organization Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Cerebrospinal Fluid Circulation Mucociliary Clearance	Thigmotaxis Regulation Of Respiratory Gaseous Exchange By Nervous System Process Cell Adhesion Neuron Cell-cell Adhesion Synapse Assembly Jump Response Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Cell Surface Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Postsynaptic Specialization Assembly Presynapse Assembly Insulin Metabolic Process Positive Regulation Of Protein Localization To Synapse Positive Regulation Of T-SNARE Clustering Inhibitory Synapse Assembly Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Cerebellum growth ( 29682794) Femur bone mineral density x serum urate levels interaction ( 34046847) Immune response to measles-mumps-rubella vaccine ( 24811271) Impulsivity ( 30718321) Myopia (pathological) ( 23049088) Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)	Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: SRPK2	8 interacting genes: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ
Entrez ID		1770	57555
HPRD ID		04511	07348
Ensembl ID		ENSG00000007174	ENSG00000169992
Uniprot IDs		Q99499 Q9NYC9	Q8NFZ4
PDB IDs		8J07	5XEQ 8GS4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-SNARE Clustering Jump Response Nuclear Speck Organization Regulation Of Protein Localization To Membrane Chloride Channel Inhibitor Activity Translational Attenuation Glycinergic Synapse Ribbon Synapse Postsynaptic Membrane Assembly Terminal Button Organization Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Inhibitory Postsynaptic Potential Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Protein Localization To Synapse Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Synaptic Vesicle Clustering Thigmotaxis R-loop Processing Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Dopaminergic Synapse Neurotransmitter-gated Ion Channel Clustering Presynapse Assembly Postsynaptic Specialization Assembly Locomotory Exploration Behavior Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Inhibitory Synapse Positive Regulation Of Synaptic Transmission, GABAergic Oocyte Development Nuclear Body Organization Insulin Metabolic Process Presynapse Organization Cell-cell Junction Maintenance Regulation Of Cellular Localization Regulation Of Respiratory Gaseous Exchange Inhibitory Synapse Assembly Early Endosome To Late Endosome Transport Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Regulation Of Protein Localization To Synapse Positive Regulation Of Viral Genome Replication Excitatory Synapse	Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Vocalization Behavior Protein Localization To Cell Junction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Cell-cell Adhesion Neuron Cell-cell Adhesion Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Trans-synaptic Signaling Ionotropic Glutamate Receptor Binding Synaptic Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Establishment Or Maintenance Of Cell Polarity Learning Cell Adhesion Gephyrin Clustering Involved In Postsynaptic Density Assembly Localization Within Membrane NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Nervous System Development Postsynaptic Membrane Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cell-cell Signaling Vocal Learning Cell Junction Assembly Signaling Learning Or Memory Postsynaptic Membrane Organization Observational Learning Cell Communication Cell Projection Cell Adhesion Molecule Binding Cognition Juxtaparanode Region Of Axon Synapse Assembly Kinase Binding Postsynaptic Density Membrane Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Mechanosensory Behavior Nervous System Process
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