ARX and NELL2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		ARX	NELL2
Description		aristaless related homeobox	neural EGFL like 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase C Binding Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Globus Pallidus Development Olfactory Bulb Development Cerebral Cortex Tangential Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Proliferation In Forebrain Cerebral Cortex GABAergic Interneuron Migration Cell Differentiation Forebrain Development Organ Growth Lipid Digestion Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Organ Growth Neuron Fate Commitment Neuron Development Regulation Of Epithelial Cell Proliferation Epithelial Cell Fate Commitment Interneuron Migration	Nervous System Development Fertilization Neuron Cellular Homeostasis Commissural Neuron Axon Guidance
Pathways			Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases		Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Early infantile epileptic encephalopathy; Ohtahara syndrome Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS			Inflammatory bowel disease ( 27569725) Waist circumference ( 28552196)
Interacting Genes		8 interacting genes: ACTN2 CYTIP DNM2 IPO13 NELL2 PKM SETD2 TLE5	9 interacting genes: ARX ATN1 ATXN7 CACNA1A DYRK1A GFI1B HOXA1 MBD1 PRKAR1A
Entrez ID		170302	4753
HPRD ID		02307	11891
Ensembl ID		ENSG00000004848	ENSG00000184613
Uniprot IDs		Q96QS3	B7Z625 Q99435
PDB IDs			6POG
Enriched GO Terms of Interacting Partners?			Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Regulation Of Metabolic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Histone H4K8ac Reader Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Metabolic Process Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Or Depolymerization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Globus Pallidus Development Negative Regulation Of Metabolic Process P-TEFb Complex Binding Histone H4 Reader Activity Lipid Digestion Cerebral Cortex Tangential Migration Negative Regulation Of Heterochromatin Formation
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