DCP2 and MX1

		DCP2	MX1
Description		decapping mRNA 2	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Cell Junction Cytoplasmic Ribonucleoprotein Granule	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	RNA Binding 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity RNA Exonuclease Activity, Producing 5'-phosphomonoesters Manganese Ion Binding Metal Ion Binding Telomerase RNA Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Histone MRNA Catabolic Process Regulation Of Telomerase RNA Localization To Cajal Body	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Waist circumference ( 32902719) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		12 interacting genes: AGO1 AGO2 DCP1A DCP1B MIR15B MTOR NAGK POLA2 PSMB1 TRIM21 UPF1 UPF2	42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		167227	4599
HPRD ID		13125	00919
Ensembl ID		ENSG00000172795	ENSG00000157601
Uniprot IDs		Q8IU60	H9KVC7 P20591
PDB IDs		5MP0 5QOH 5QOI 5QOJ 5QOK 5QOL 5QOM 5QON 5QOO 5QOP 5QOQ 5QOR 5QOS 5QOT 5QOU 5QOV 5QOW 5QOX 5QOY 5QOZ 5QP0 5QP1 5QP2 5QP3 5QP4 5QP5 5QP6 5QP7 5QP8 5QP9 5QPA 5QPB 5QPC	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?		P-body Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process RNA Catabolic Process Cytoplasmic Ribonucleoprotein Granule SiRNA-mediated Gene Silencing By MRNA Destabilization Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Gene Expression Positive Regulation Of Catabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation RISC-loading Complex Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Translation RISC Complex Assembly 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytosol Regulation Of Translation RNA Metabolic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing RISC Complex Autophagosome Assembly Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping MRNA Destabilization Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Autophagosome Organization Negative Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Non-canonical NF-kappaB Signal Transduction RNA Decapping Exon-exon Junction Complex MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process MiRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Telomeric DNA Binding Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Polymerase II Complex Binding Positive Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Processing	Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing
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