CCDC138 and CEP57

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCDC138	CEP57
Description		coiled-coil domain containing 138	centrosomal protein 57
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Gamma-tubulin Binding
	Biological Process		Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)	Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 24390342 30423114) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		11 interacting genes: BOLA2 BOLA2B CDC37 CEP57 FAM161B KRT27 PIBF1 PKN1 TCEANC TRAF3IP3 UBAC1	47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1
Entrez ID		165055	9702
HPRD ID		08136	16261
Ensembl ID		ENSG00000163006	ENSG00000166037
Uniprot IDs		Q96M89	F5GYW0 Q86XR8
PDB IDs			4L0R 8IBH
Enriched GO Terms of Interacting Partners?		Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly 2 Iron, 2 Sulfur Cluster Binding Iron-sulfur Cluster Assembly Cell Redox Homeostasis Protein Maturation Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Binding Negative Regulation Of Prostaglandin Biosynthetic Process HSP90-CDC37 Chaperone Complex	Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Epithelial Cell Differentiation Keratinization Negative Regulation Of Protein Acetylation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Post-translational Protein Modification De Novo Centriole Assembly Structural Molecule Activity DNA-binding Transcription Factor Binding Protein Binding Regulation Of Protein Ubiquitination Organelle Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Intermediate Filament Cytoskeleton Negative Regulation Of Protein Sumoylation Chromatin Organization Positive Regulation Of Neural Precursor Cell Proliferation B Cell Apoptotic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Fate Commitment Positive Regulation Of Ubiquitin-protein Transferase Activity Intracellular Signal Transduction Tissue Morphogenesis Centriole
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