AKR1C1 and PTPN3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AKR1C1	PTPN3
Gene Name		aldo-keto reductase family 1, member C1	protein tyrosine phosphatase, non-receptor type 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Carboxylic Acid Binding Bile Acid Binding 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Retinoid Metabolic Process Xenobiotic Metabolic Process Digestion Phototransduction, Visible Light Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Protein Homooligomerization Oxidation-reduction Process Cellular Response To Jasmonic Acid Stimulus	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Bile acid and bile salt metabolism Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Synthesis of bile acids and bile salts Retinoid metabolism and transport
Drugs		NADH Salicyclic acid Acetylsalicylic acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 2-HYDROXY-3,5-DIIODOBENZOIC ACID (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol
Diseases
GWAS		Economic and political preferences (immigration/crime) ( 22566634)
Protein-Protein Interactions		3 interactors: COMMD8 MAPK3 PTPN3	14 interactors: ADAM17 AKR1C1 CD247 DIP2A GHR LMO1 NXT2 VCP WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		1645	5774
HPRD ID		07194	06767
Ensembl ID			ENSG00000070159
Uniprot IDs		Q04828	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs		1MRQ 3C3U 3GUG 3NTY	2B49
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apolipoprotein Binding Regulation Of Golgi Inheritance Liver Regeneration Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport DNA Damage Induced Protein Phosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Histone Acetylation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Peptidyl-lysine Acetylation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Acetylation Cellular Response To Growth Hormone Stimulus Transcription Initiation From RNA Polymerase I Promoter Regulation Of Sodium Ion Transmembrane Transporter Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Transcription From RNA Polymerase I Promoter Regulation Of Membrane Depolarization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Response To Exogenous DsRNA Regulation Of Histone Acetylation Negative Regulation Of Protein Binding Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat Activation Of MAPKK Activity Regulation Of Sodium Ion Transport MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To DsRNA MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Positive Regulation Of Histone Modification Organ Regeneration BMP Signaling Pathway	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Cellular Response To Hormone Stimulus Regulation Of Mitochondrion Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Peptide Hormone Growth Hormone Receptor Signaling Pathway Regulation Of Cell Death Cellular Response To Organonitrogen Compound Cellular Response To Growth Hormone Stimulus Response To Hormone Response To Peptide Apoptotic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Response To Growth Hormone Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Cell Death Positive Regulation Of Intracellular Transport Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Protein Transport Signaling T Cell Differentiation In Thymus Regulation Of Kinase Activity Cell Communication Establishment Of Protein Localization Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Beta Selection Positive Regulation Of Protein Modification Process
Tagcloud ?		11beta 9alpha abcc4 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases	adaptor advance border cascades dephosphorylation doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Difference) ?		11beta 9alpha abcc4 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases	adaptor advance border cascades dephosphorylation doi dptpmeg drosophila egfr endocytosis eps15 ferm homolog impairs lysosomal morphogenesis onc oncogene online pdz publication raft scaffolding september suppress trafficking tumorigenicity wing xenograft
Tagcloud (Intersection) ?