AKR1C1 and COMMD8

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		AKR1C1	COMMD8
Gene Name		aldo-keto reductase family 1, member C1	COMM domain containing 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Carboxylic Acid Binding Bile Acid Binding 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Xenobiotic Metabolic Process Digestion Phototransduction, Visible Light Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Protein Homooligomerization Oxidation-reduction Process Cellular Response To Jasmonic Acid Stimulus
Pathways		Bile acid and bile salt metabolism Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Synthesis of bile acids and bile salts Retinoid metabolism and transport
Drugs		NADH Salicyclic acid Acetylsalicylic acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 2-HYDROXY-3,5-DIIODOBENZOIC ACID (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol
Diseases
GWAS		Economic and political preferences (immigration/crime) ( 22566634)
Protein-Protein Interactions		3 interactors: COMMD8 MAPK3 PTPN3	5 interactors: AKR1C1 COMMD1 COMMD3 NDUFA4L2 TMX2
Entrez ID		1645	54951
HPRD ID		07194	13086
Ensembl ID			ENSG00000169019
Uniprot IDs		Q04828	Q9NX08
PDB IDs		1MRQ 3C3U 3GUG 3NTY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apolipoprotein Binding Regulation Of Golgi Inheritance Liver Regeneration Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport DNA Damage Induced Protein Phosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Histone Acetylation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Peptidyl-lysine Acetylation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Acetylation Cellular Response To Growth Hormone Stimulus Transcription Initiation From RNA Polymerase I Promoter Regulation Of Sodium Ion Transmembrane Transporter Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Transcription From RNA Polymerase I Promoter Regulation Of Membrane Depolarization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Response To Exogenous DsRNA Regulation Of Histone Acetylation Negative Regulation Of Protein Binding Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat Activation Of MAPKK Activity Regulation Of Sodium Ion Transport MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To DsRNA MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Positive Regulation Of Histone Modification Organ Regeneration BMP Signaling Pathway	Homeostatic Process Cellular Response To Jasmonic Acid Stimulus Negative Regulation Of Sodium Ion Transmembrane Transport Plasma Membrane To Endosome Transport Daunorubicin Metabolic Process Doxorubicin Metabolic Process Intestinal Cholesterol Absorption Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transport Lipid Digestion Retinal Metabolic Process Glycoside Metabolic Process Regulation Of Protein Localization To Cell Surface Progesterone Metabolic Process Copper Ion Homeostasis Intestinal Absorption C21-steroid Hormone Metabolic Process Chemical Homeostasis Bile Acid And Bile Salt Transport Golgi To Plasma Membrane Transport Regulation Of Sodium Ion Transmembrane Transport Bile Acid Metabolic Process Quinone Metabolic Process Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sodium Ion Transport Sterol Transport Cholesterol Transport Phototransduction, Visible Light Cellular Aldehyde Metabolic Process Cholesterol Homeostasis Retinoid Metabolic Process Cellular Ketone Metabolic Process Sterol Homeostasis Diterpenoid Metabolic Process Post-Golgi Vesicle-mediated Transport Detection Of Visible Light Phototransduction Negative Regulation Of Ion Transport Detection Of Light Stimulus Lipid Homeostasis Digestion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Isoprenoid Metabolic Process Cell Redox Homeostasis
Tagcloud ?		11beta 9alpha abcc4 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		11beta 9alpha abcc4 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?