AKR1C1 and COMMD8

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		AKR1C1	COMMD8
Description		aldo-keto reductase family 1 member C1	COMM domain containing 8
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carboxylic Acid Binding Bile Acid Binding 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity	Protein Binding NF-kappaB Binding
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Cellular Response To Jasmonic Acid Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport Prednisone ADME	Neddylation
Drugs		NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hip index ( 34021172) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		3 interacting genes: COMMD8 MAPK3 PTPN3	5 interacting genes: AKR1C1 COMMD1 COXFA4L2 TMX2 ZNF474
Entrez ID		1645	54951
HPRD ID		07194	13086
Ensembl ID		ENSG00000187134	ENSG00000169019
Uniprot IDs		Q04828	Q9NX08
PDB IDs		1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX 8JP2	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Proteolysis Phosphotyrosine Residue Binding Regulation Of Proteolysis Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Interleukin-34-mediated Signaling Pathway Positive Regulation Of Leukocyte Migration Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Golgi Inheritance GLI-SUFU Complex Positive Regulation Of Xenophagy Regulation Of Leukocyte Migration Cardiac Neural Crest Cell Development Involved In Heart Development Caveolin-mediated Endocytosis MAPK Cascade Xenophagy Positive Regulation Of Macrophage Proliferation Trachea Formation Regulation Of Intracellular Transport Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Tumor Necrosis Factor Receptor Activity Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Cholesterol Efflux Negative Regulation Of Immune Response To Tumor Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Cholesterol Transport Positive Regulation Of Neuroinflammatory Response Regulation Of Golgi Organization Regulation Of T Cell Mediated Immune Response To Tumor Cell MAP Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Signal Transduction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Indanol Dehydrogenase Activity Sterol Homeostasis 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Cellular Response To Jasmonic Acid Stimulus Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Cholesterol Homeostasis Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Ketosteroid Monooxygenase Activity Lipid Homeostasis Regulation Of Plasma Lipoprotein Particle Levels 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Regulation Of Cholesterol Import Daunorubicin Metabolic Process Carboxylic Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Doxorubicin Metabolic Process Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Testosterone Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Bile Acid Binding Disulfide Oxidoreductase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Intestinal Cholesterol Absorption Aldose Reductase (NADPH) Activity Plasma Membrane To Endosome Transport Alcohol Dehydrogenase (NADP+) Activity Negative Regulation Of Protein Localization To Cell Surface Intestinal Lipid Absorption Negative Regulation Of Cellular Response To Hypoxia Progesterone Metabolic Process Negative Regulation Of Sodium Ion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Lipid Binding Low-density Lipoprotein Particle Clearance Retinal Metabolic Process Respiratory Chain Complex IV Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Bile Acid And Bile Salt Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Cellular Response To Hypoxia
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