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AKR1C1
Description
aldo-keto reductase family 1 member C1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Aldose Reductase (NADPH) Activity
Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity
Protein Binding
Alcohol Dehydrogenase (NADP+) Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor
Carboxylic Acid Binding
Bile Acid Binding
3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity
Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity
Androsterone Dehydrogenase [NAD(P)+] Activity
5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity
Testosterone Dehydrogenase (NADP+) Activity
Ketosteroid Monooxygenase Activity
Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity
Indanol Dehydrogenase Activity
3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity
Biological Process
Retinoid Metabolic Process
Alcohol Metabolic Process
Lipid Metabolic Process
Prostaglandin Metabolic Process
Xenobiotic Metabolic Process
Digestion
Steroid Metabolic Process
Bile Acid Metabolic Process
Bile Acid And Bile Salt Transport
Intestinal Cholesterol Absorption
Epithelial Cell Differentiation
Monocarboxylic Acid Metabolic Process
Hormone Metabolic Process
Progesterone Metabolic Process
Retinal Metabolic Process
Cholesterol Homeostasis
Daunorubicin Metabolic Process
Doxorubicin Metabolic Process
Cellular Response To Jasmonic Acid Stimulus
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Retinoid metabolism and transport
Prednisone ADME
Drugs
NADH
Salicylic acid
Acetylsalicylic acid
Nicotinamide adenine dinucleotide phosphate
Naringenin
2-HYDROXY-3,5-DIIODOBENZOIC ACID
Epitestosterone
Hexestrol
Diseases
GWAS
Economic and political preferences (immigration/crime) (
22566634
)
Height (
25282103
)
Hip index (
34021172
)
Hypopharyngeal or laryngeal cancer (
32276964
)
Lung cancer (
28604730
)
Metabolite levels (
23823483
)
Squamous cell lung carcinoma (
28604730
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Novel Interacting Genes
2 novel interacting genes:
SUFU
TNFRSF18
Interacting Genes
3 interacting genes:
COMMD8
MAPK3
PTPN3
Entrez ID
1645
HPRD ID
07194
Ensembl ID
ENSG00000187134
Uniprot IDs
Q04828
PDB IDs
1MRQ
3C3U
3GUG
3NTY
4YVP
6A7A
6IJX
8JP2
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Proteolysis
Phosphotyrosine Residue Binding
Regulation Of Proteolysis
Negative Regulation Of Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Response To Drug
Positive Regulation Of Cellular Response To Drug
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification
Positive Regulation Of Response To Drug
Interleukin-34-mediated Signaling Pathway
Positive Regulation Of Leukocyte Migration
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification
Signal Transduction
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Golgi Inheritance
GLI-SUFU Complex
Positive Regulation Of Xenophagy
Regulation Of Leukocyte Migration
Cardiac Neural Crest Cell Development Involved In Heart Development
Caveolin-mediated Endocytosis
MAPK Cascade
Xenophagy
Positive Regulation Of Macrophage Proliferation
Trachea Formation
Regulation Of Intracellular Transport
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Membrane Depolarization During Action Potential
Regulation Of Response To Drug
Spinal Cord Dorsal/ventral Patterning
Outer Ear Morphogenesis
Peptidyl-tyrosine Autophosphorylation
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Bergmann Glial Cell Differentiation
Tumor Necrosis Factor Receptor Activity
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Negative Regulation Of Cholesterol Efflux
Negative Regulation Of Immune Response To Tumor Cell
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cholesterol Transport
Positive Regulation Of Neuroinflammatory Response
Regulation Of Golgi Organization
Regulation Of T Cell Mediated Immune Response To Tumor Cell
MAP Kinase Activity
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Tagcloud
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