CITED4 and TFAP2A

Number of citations of the paper that reports this interaction (PubMedID 11744733)
0

Data Source:
HPRD (in vitro)

		CITED4	TFAP2A
Description		Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4	transcription factor AP-2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coactivator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Response To Estrogen Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of DNA-templated Transcription Nervous System Development Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of the TFAP2 (AP-2) family of transcription factors	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Positive Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Specification of the neural plate border Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases			Branchiooculofacial syndrome (BOFS)
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)
Interacting Genes		4 interacting genes: EP300 TFAP2A TFAP2B TFAP2C	40 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 INCA1 KCTD15 LDLRAP1 MAGI1 MARK1 MKRN3 MYC NFKB1 NPM1 OCRL PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1
Entrez ID		163732	7020
HPRD ID		06011	00128
Ensembl ID		ENSG00000179862	ENSG00000137203
Uniprot IDs		Q96RK1	A0A6E1XE14 P05549
PDB IDs			8J0K 8J0L 8J0R
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Retina Layer Formation Forelimb Morphogenesis RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Skin Development DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Animal Organ Development Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Propionylation Anatomical Structure Morphogenesis Swimming Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Metabolic Process Peptidyl-lysine Butyrylation Negative Regulation Of DNA-templated Transcription Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Chromatin Binding Histone Crotonyltransferase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Optic Cup Structural Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Programmed Cell Death Nervous System Development Sequence-specific Double-stranded DNA Binding Limb Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Positive Regulation Of RNA Metabolic Process Protein Propionyltransferase Activity Fat Cell Differentiation Positive Regulation Of T Cell Differentiation Histone H3K27 Acetyltransferase Activity	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Cell Death Negative Regulation Of DNA-templated Transcription Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Clathrin Binding Cell Surface Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Signaling Regulation Of Metabolic Process Transcription Coregulator Binding Regulation Of Protein Localization Regulation Of Signal Transduction Signal Transduction Cytosol Myeloid Cell Differentiation Chromatin Binding Glial Cell Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II Disordered Domain Specific Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process
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