CFAP58 and MCC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CFAP58	MCC
Description		cilia and flagella associated protein 58	MCC regulator of Wnt signaling pathway
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Centrosome Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Sperm Midpiece	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Notch Signaling Pathway Sperm Axoneme Assembly Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Protein Localization To Motile Cilium Sperm Flagellum Assembly Sperm Mitochondrial Sheath Assembly	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: APP BACH2 FBXL17 KRT27 MCC NAV2 RIPPLY1	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		159686	4163
HPRD ID		16583	01157
Ensembl ID		ENSG00000120051	ENSG00000171444
Uniprot IDs		Q5T655	P23508
PDB IDs		8J07	6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Primary Adaptive Immune Response Involving T Cells And B Cells Glossopharyngeal Nerve Development Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Vagus Nerve Development Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Low-density Lipoprotein Particle Mediated Signaling Primary Adaptive Immune Response Somite Specification Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Locomotory Behavior Axon Choice Point Recognition Interstitial Matrix Cerebellar Cortex Development Heparan Sulfate Binding Signaling Receptor Activator Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Peptidase Activator Activity Cellular Response To Manganese Ion	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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