ADSL and CCN3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADSL	CCN3
Description		adenylosuccinate lyase	cellular communication network factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol Gap Junction Extracellular Matrix Anchoring Junction
	Molecular Function	Catalytic Activity N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Lyase Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) Succinate Lyase (fumarate-forming) Activity	Signaling Receptor Binding Notch Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Heparin Binding
	Biological Process	Response To Hypoxia Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Response To Nutrient Aerobic Respiration Purine Ribonucleotide Biosynthetic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process AMP Salvage 'de Novo' XMP Biosynthetic Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Ossification Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs			Insulin human
Diseases		Adenylosuccinate lyase deficiency
GWAS		Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		4 interacting genes: CALCOCO2 CCN3 OGT REL	31 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 FXR1 FXR2 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330
Entrez ID		158	4856
HPRD ID		00049	01291
Ensembl ID		ENSG00000239900	ENSG00000136999
Uniprot IDs		A0A1B0GTG9 A0A1B0GWJ0 A0A7P0T8E4 A0A7P0Z472 P30566 X5D7W4 X5D8S6	P48745
PDB IDs		2J91 2VD6 4FFX 4FLC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Sensory Perception Of Pain Endothelial Cell-cell Adhesion Bone Regeneration NF-kappaB Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Autophagy Positive Regulation Of Transcription By Glucose Macroautophagy Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Smooth Muscle Cell Proliferation Negative Regulation Of Cell Migration Regulation Of Transcription By Glucose Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Endothelial Cell Chemotaxis NSL Complex Smooth Muscle Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Interferon-beta Production Regulation Of Autophagosome Maturation Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Communication Negative Regulation Of Nervous System Process Epithelial Cell-cell Adhesion Type B Pancreatic Cell Proliferation Positive Regulation Of Signaling Fibroblast Migration Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Sensory Perception Of Pain Negative Regulation Of Leukocyte Chemotaxis Sin3-type Complex Gap Junction Hematopoietic Stem Cell Homeostasis Regulation Of Intracellular Signal Transduction Muscle Cell Migration Notch Binding Response To Peptide	Tissue Development Epidermis Development Integrin Binding Positive Regulation Of Growth Positive Regulation Of Developmental Growth Regulation Of Growth Regulation Of Developmental Growth Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Receptor Ligand Activity Insulin-like Growth Factor Receptor Binding Positive Regulation Of Glycogen Biosynthetic Process Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Cell Development Regulation Of Nervous System Development Insulin Receptor Binding Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Angiogenesis Positive Regulation Of Cell Differentiation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Regulation Of Glycogen Biosynthetic Process Basement Membrane Negative Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Response To Wounding Extracellular Region Positive Regulation Of Cell Communication Positive Regulation Of Signaling Integrin-mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Growth Endodermal Cell Differentiation Positive Regulation Of D-glucose Import Cell-matrix Adhesion Regulation Of Neurogenesis Regulation Of Glycogen Metabolic Process Regulation Of Somitogenesis Positive Regulation Of Neurogenesis Regulation Of Skeletal Muscle Tissue Growth
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?