ADSL

Description		adenylosuccinate lyase
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GO Annotations	Cellular Component	Cytosol Protein-containing Complex
	Molecular Function	Catalytic Activity N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Lyase Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) Succinate Lyase (fumarate-forming) Activity
	Biological Process	Response To Hypoxia Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Response To Nutrient Aerobic Respiration Purine Ribonucleotide Biosynthetic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process AMP Salvage 'de Novo' XMP Biosynthetic Process
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs
Diseases		Adenylosuccinate lyase deficiency
GWAS		Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		4 interacting genes: CALCOCO2 CCN3 OGT REL
Entrez ID		158
HPRD ID		00049
Ensembl ID		ENSG00000239900
Uniprot IDs		A0A1B0GTG9 A0A1B0GWJ0 A0A7P0T8E4 A0A7P0Z472 P30566 X5D7W4 X5D8S6
PDB IDs		2J91 2VD6 4FFX 4FLC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Sensory Perception Of Pain Endothelial Cell-cell Adhesion Bone Regeneration NF-kappaB Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Autophagy Positive Regulation Of Transcription By Glucose Macroautophagy Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Smooth Muscle Cell Proliferation Negative Regulation Of Cell Migration Regulation Of Transcription By Glucose Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Endothelial Cell Chemotaxis NSL Complex Smooth Muscle Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Interferon-beta Production Regulation Of Autophagosome Maturation Negative Regulation Of Myotube Differentiation Positive Regulation Of Cell Communication Negative Regulation Of Nervous System Process Epithelial Cell-cell Adhesion Type B Pancreatic Cell Proliferation Positive Regulation Of Signaling Fibroblast Migration Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Sensory Perception Of Pain Negative Regulation Of Leukocyte Chemotaxis Sin3-type Complex Gap Junction Hematopoietic Stem Cell Homeostasis Regulation Of Intracellular Signal Transduction Muscle Cell Migration Notch Binding Response To Peptide
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