METTL27 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		METTL27	NOXA1
Description		methyltransferase like 27	NADPH oxidase activator 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Plasma Membrane Membrane NADPH Oxidase Complex
	Molecular Function	Protein Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding Identical Protein Binding
	Biological Process		Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Respiratory Burst
Pathways			RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS			Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		29 interacting genes: A1CF ATXN1 ATXN1L CCDC120 CSTF2 DOK6 EFHC1 ENKD1 FOXC2 GLYCTK GPANK1 GRB2 HGS KDM1A LMO4 NOXA1 PITX1 PRKAB2 PRMT6 PROP1 SAXO4 SNRPC TBX6 TEKT3 TFG TLX3 VPS37C ZIC1 ZNF77	57 interacting genes: ACTMAP ANKRD55 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 SPMIP6 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620
Entrez ID		155368	10811
HPRD ID		15661	17644
Ensembl ID		ENSG00000165171	ENSG00000188747
Uniprot IDs		Q8N6F8	Q86UR1
PDB IDs			7CFZ
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Regulation Of Respiratory Burst Respiratory Burst Regulation Of Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Manchette Benzodiazepine Receptor Binding Erythrocyte Enucleation Protein Binding Intermediate Filament Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Cytokine Production Superoxide-generating NADPH Oxidase Activator Activity Intracellular Signaling Cassette Internal Protein Amino Acid Acetylation Negative Regulation Of Glial Cell Apoptotic Process Thioesterase Binding
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