METTL27 and FOXC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		METTL27	FOXC2
Description		methyltransferase like 27	forkhead box C2
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Metanephros Development Ureteric Bud Development Somitogenesis Kidney Development Lymph Vessel Development Lymphangiogenesis Blood Vessel Remodeling Heart Morphogenesis Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Heart Development Cell Population Proliferation Insulin Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Endothelial Cell Migration Neural Crest Cell Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Embryonic Heart Tube Development Positive Regulation Of Vascular Wound Healing Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Paraxial Mesodermal Cell Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Glomerular Endothelium Development Podocyte Differentiation Glomerular Mesangial Cell Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Diameter Maintenance Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Pathways			Formation of intermediate mesoderm Formation of the ureteric bud
Drugs
Diseases			Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS			Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		29 interacting genes: A1CF ATXN1 ATXN1L CCDC120 CSTF2 DOK6 EFHC1 ENKD1 FOXC2 GLYCTK GPANK1 GRB2 HGS KDM1A LMO4 NOXA1 PITX1 PRKAB2 PRMT6 PROP1 SAXO4 SNRPC TBX6 TEKT3 TFG TLX3 VPS37C ZIC1 ZNF77	8 interacting genes: CNOT7 GOLGA2 KRTAP3-3 METTL27 NPHS2 RBPMS TAX1BP1 TRIM27
Entrez ID		155368	2303
HPRD ID		15661	03869
Ensembl ID		ENSG00000165171	ENSG00000176692
Uniprot IDs		Q8N6F8	Q99958
PDB IDs			1D5V 6AKO 6AKP 6LBM 6O3T
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Axonemal A Tubule Inner Sheath Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
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