PIK3C2A

Gene Name		phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Clathrin-coated Vesicle Vesicle Extracellular Vesicular Exosome
	Molecular Function	ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Vascular Smooth Muscle Contraction Phosphatidylinositol-3-phosphate Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Clathrin Coat Assembly Negative Regulation Of Zinc Ion Transmembrane Transport
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Golgi Associated Vesicle Biogenesis Phospholipid metabolism trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Synthesis of PIPs at the late endosome membrane PI Metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: EGFR ERBB2
Entrez ID		5286
HPRD ID		04672
Ensembl ID		ENSG00000011405
Uniprot IDs		F5H2B0 L7RRS0 O00443
PDB IDs		2AR5 2IWL 2REA 2RED
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Glial Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Alkanesulfonate Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Gliogenesis Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Epithelial Cell Proliferation Regulation Of MAP Kinase Activity Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Negative Regulation Of Immature T Cell Proliferation In Thymus Activation Of Phospholipase A2 Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Cobalamin Response To UV-A Axonogenesis Response To Hydroxyisoflavone Positive Regulation Of Transferase Activity Axon Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Negative Regulation Of T Cell Differentiation In Thymus Regulation Of MAPK Cascade Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase III Promoter
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x