AMOT and LATS2

Number of citations of the paper that reports this interaction (PMID 24255178)
8

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, enzymatic study, enzymatic study, enzymatic study)

		AMOT	LATS2
Gene Name		angiomotin	large tumor suppressor kinase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Lamellipodium Endocytic Vesicle	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol
	Molecular Function	Receptor Activity Protein Binding Angiostatin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ACTA1 APP C1orf216 KRT15 KRT31 LATS1 LATS2 LMO4 LURAP1 MAGEA4 MAGI1 MAPK3 MED4 NEDD4 PIN1 PLG PPP2R4 SEPT1 SNAPC5 UNC119 WDYHV1	19 interactors: ABL1 AJUBA AMOT AURKB CDK2 CDKN1A CHEK1 CHEK2 CTNNB1 DYRK1A MOB3A MOB3B MOB3C MOB4 SNAI1 STK3 TAZ YAP1 YWHAG
Entrez ID		154796	26524
HPRD ID		02327	07277
Ensembl ID		ENSG00000126016	ENSG00000150457
Uniprot IDs		Q4VCS5	Q9NRM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Tissue Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Epidermis Development Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Hippo Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Phosphorylation Cell Division Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Platelet Activation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Apolipoprotein Binding Transmission Of Virus Development Involved In Symbiotic Interaction Neuromuscular Junction Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Neuron Death Regulation Of Sodium Ion Transport Epithelium Development Negative Regulation Of Signal Transduction Protein Peptidyl-prolyl Isomerization Platelet Degranulation Response To Abiotic Stimulus Intracellular Steroid Hormone Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Caveolin-mediated Endocytosis Organ Development	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Hippo Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Cell Cycle Phase Transition DNA Damage Induced Protein Phosphorylation Positive Regulation Of Stem Cell Differentiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Developmental Process Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Protein Autophosphorylation Cell Cycle Checkpoint Negative Regulation Of Signaling Negative Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signaling Regulation Of Cell Cycle Process Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Regulation Of Response To DNA Damage Stimulus Histone Phosphorylation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Radiation Apoptotic Signaling Pathway
Tagcloud ?		actin alanine amotl2 amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	address approach bioinformatics carried challenging contribute damage discovery efficiently especially genome hlats1 lats1 mutations numerous opportunities powerful predicted projects putative question regulators silico sort support suppressor suppressors understood unprecedented
Tagcloud (Difference) ?		actin alanine amotl2 amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	address approach bioinformatics carried challenging contribute damage discovery efficiently especially genome hlats1 mutations numerous opportunities powerful predicted projects putative question regulators silico sort support suppressor suppressors understood unprecedented
Tagcloud (Intersection) ?		lats1 lats2