CX3CR1 and CX3CL1

Number of citations of the paper that reports this interaction (PubMedID 9931005)
0

Data Source:
HPRD (in vitro, in vivo)

		CX3CR1	CX3CL1
Description		C-X3-C motif chemokine receptor 1	C-X3-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree Macropinosome Membrane	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding CX3C Chemokine Receptor Binding	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity CX3C Chemokine Receptor Binding Chemoattractant Activity CXCR1 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Adaptive Immune Response Microglial Cell Activation Involved In Immune Response Immune System Process Response To Ischemia Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Brain Development Response To Wounding Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Central Nervous System Maturation Leukocyte Chemotaxis Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Synaptic Plasticity Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Maturation Cell Chemotaxis Antifungal Innate Immune Response Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Regulation Of Microglial Cell Migration Negative Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Signaling Pathway	Microglial Cell Activation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Leukocyte Migration Involved In Inflammatory Response Response To Ischemia Chemotaxis Defense Response Inflammatory Response Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Neuron Remodeling Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Neutrophil Chemotaxis Leukocyte Chemotaxis Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Integrin Activation Autocrine Signaling Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Leukocyte Adhesive Activation Positive Chemotaxis Positive Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Cell Chemotaxis Microglial Cell Proliferation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neuron Cellular Homeostasis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Alanine aminotransferase levels ( 34315874) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		2 interacting genes: CCDC167 CX3CL1	1 interacting genes: CX3CR1
Entrez ID		1524	6376
HPRD ID		03277	03529
Ensembl ID		ENSG00000168329	ENSG00000006210
Uniprot IDs		P49238	A0N0N7 P78423
PDB IDs		7XBW 7XBX	1B2T 1F2L 3ONA 4XT1 4XT3 5WB2 7RKF 7RKM 7RKN 7XBX
Enriched GO Terms of Interacting Partners?		Leukocyte Adhesive Activation Negative Regulation Of Interleukin-1 Alpha Production CXCR1 Chemokine Receptor Binding Positive Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Glutamate Receptor Signaling Pathway CX3C Chemokine Receptor Binding Negative Regulation Of Hippocampal Neuron Apoptotic Process Integrin Activation Microglial Cell Proliferation Negative Regulation Of Microglial Cell Activation Autocrine Signaling Positive Regulation Of Glial Cell Migration Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Microglial Cell Migration Regulation Of Glutamate Receptor Signaling Pathway Synapse Pruning Regulation Of Hippocampal Neuron Apoptotic Process Neuron Remodeling Macrophage Chemotaxis Angiogenesis Involved In Wound Healing Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Regulation Of Microglial Cell Activation Positive Regulation Of Transforming Growth Factor Beta Production Leukocyte Migration Involved In Inflammatory Response Eosinophil Migration Eosinophil Chemotaxis Regulation Of Glial Cell Migration Macrophage Migration Lymphocyte Chemotaxis Glial Cell Proliferation Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Positive Regulation Of Neuroblast Proliferation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neuron Maturation Microglial Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chemoattractant Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Interleukin-1 Beta Production Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of Neuroinflammatory Response Regulation Of Neuroblast Proliferation Positive Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Multiple Spine Synapse Organization, Single Dendrite C-X3-C Chemokine Receptor Activity Negative Regulation Of Microglial Cell Mediated Cytotoxicity Macropinosome Membrane Central Nervous System Maturation CX3C Chemokine Receptor Binding Dendritic Tree Microglial Cell Activation Involved In Immune Response Regulation Of Hippocampal Neuron Apoptotic Process C-X3-C Chemokine Binding Negative Regulation Of Hippocampal Neuron Apoptotic Process Autocrine Signaling Regulation Of Microglial Cell Migration Host-mediated Modulation Of Intestinal Microbiota Composition Synapse Pruning Antifungal Innate Immune Response Synapse Maturation Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Macrophage Activation Involved In Immune Response Leukocyte Tethering Or Rolling C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Glial Cell Migration Neuronal Cell Body Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Interleukin-1 Beta Production Microglial Cell Activation Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response G Protein-coupled Peptide Receptor Activity Negative Regulation Of Interleukin-1 Production Regulation Of Neuroblast Proliferation Regulation Of Macrophage Migration Cellular Defense Response Cytokine Receptor Activity Defense Response To Fungus Social Behavior Leukocyte Cell-cell Adhesion Positive Regulation Of Neural Precursor Cell Proliferation Response To Fungus Response To Ischemia Regulation Of Nitric Oxide Biosynthetic Process Macrophage Activation Regulation Of Nitric Oxide Metabolic Process Chemokine-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Migration Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis
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