CX3CR1

Description		C-X3-C motif chemokine receptor 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Neuron Projection Perinuclear Region Of Cytoplasm Dendritic Tree Macropinosome Membrane
	Molecular Function	Cytokine Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity C-C Chemokine Receptor Activity C-X3-C Chemokine Receptor Activity C-C Chemokine Binding C-X3-C Chemokine Binding CX3C Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Adaptive Immune Response Microglial Cell Activation Involved In Immune Response Immune System Process Response To Ischemia Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Brain Development Response To Wounding Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Central Nervous System Maturation Leukocyte Chemotaxis Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-1 Beta Production Social Behavior Autocrine Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Synaptic Plasticity Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synapse Maturation Cell Chemotaxis Antifungal Innate Immune Response Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Monocyte Chemotaxis Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Multiple Spine Synapse Organization, Single Dendrite Regulation Of Microglial Cell Migration Negative Regulation Of Microglial Cell Mediated Cytotoxicity Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Alanine aminotransferase levels ( 34315874) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 34315874) Autoimmune thyroid disease ( 32581359) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime sleep phenotypes ( 27126917) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: CCDC167 CX3CL1
Entrez ID		1524
HPRD ID		03277
Ensembl ID		ENSG00000168329
Uniprot IDs		P49238
PDB IDs		7XBW 7XBX
Enriched GO Terms of Interacting Partners?		Leukocyte Adhesive Activation Negative Regulation Of Interleukin-1 Alpha Production CXCR1 Chemokine Receptor Binding Positive Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Glutamate Receptor Signaling Pathway CX3C Chemokine Receptor Binding Negative Regulation Of Hippocampal Neuron Apoptotic Process Integrin Activation Microglial Cell Proliferation Negative Regulation Of Microglial Cell Activation Autocrine Signaling Positive Regulation Of Glial Cell Migration Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Microglial Cell Migration Regulation Of Glutamate Receptor Signaling Pathway Synapse Pruning Regulation Of Hippocampal Neuron Apoptotic Process Neuron Remodeling Macrophage Chemotaxis Angiogenesis Involved In Wound Healing Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Regulation Of Microglial Cell Activation Positive Regulation Of Transforming Growth Factor Beta Production Leukocyte Migration Involved In Inflammatory Response Eosinophil Migration Eosinophil Chemotaxis Regulation Of Glial Cell Migration Macrophage Migration Lymphocyte Chemotaxis Glial Cell Proliferation Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Positive Regulation Of Neuroblast Proliferation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neuron Maturation Microglial Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Chemoattractant Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Interleukin-1 Beta Production Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of Neuroinflammatory Response Regulation Of Neuroblast Proliferation Positive Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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