CST5

Description		cystatin D
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Vesicle Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (change over time) in cancer or chronic obstructive pulmonary disease ( 28044437) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Response to TNF antagonist treatment ( 18615156)
Interacting Genes		1 interacting genes: CTSS
Entrez ID		1473
HPRD ID		00463
Ensembl ID		ENSG00000170367
Uniprot IDs		P28325
PDB IDs		1RN7 1ROA
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Endolysosome Lumen Positive Regulation Of Ion Transmembrane Transporter Activity Response To Acidic PH Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding Cellular Response To Thyroid Hormone Stimulus Regulation Of Antigen Processing And Presentation Laminin Binding Basement Membrane Disassembly Response To PH Positive Regulation Of Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Response To Thyroid Hormone Basement Membrane Organization Proteoglycan Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Antigen Toll-like Receptor Signaling Pathway Extracellular Matrix Disassembly Tertiary Granule Lumen Antigen Processing And Presentation Of Peptide Antigen Collagen Binding Collagen Metabolic Process Cysteine-type Endopeptidase Activity Regulation Of Transmembrane Transporter Activity Phagocytic Vesicle Regulation Of Monoatomic Ion Transmembrane Transporter Activity Lysosomal Lumen Antigen Processing And Presentation Positive Regulation Of Cation Transmembrane Transport Ficolin-1-rich Granule Lumen Positive Regulation Of Monoatomic Ion Transmembrane Transport Cysteine-type Peptidase Activity Serine-type Endopeptidase Activity Late Endosome Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Protein Processing Positive Regulation Of Monoatomic Ion Transport Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Adaptive Immune Response Positive Regulation Of Innate Immune Response Protein Maturation
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