TCF23 and EMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCF23	EMD
Description		transcription factor 23	emerin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Cytosol Microtubule Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum TMEM240-body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Developmental Process Decidualization Negative Regulation Of Muscle Cell Differentiation	Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation
Pathways			Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Emery-Dreifuss muscular dystrophy
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		4 interacting genes: EMD FIGLA HNRNPK U2AF2	100 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AQP6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SLC10A1 SLC35H1 SOWAHB SRC SSMEM1 STX1A SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAV1 WEE2-AS1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774
Entrez ID		150921	2010
HPRD ID		18734	02309
Ensembl ID		ENSG00000163792	ENSG00000102119
Uniprot IDs		Q7RTU1	P50402
PDB IDs			1JEI 2ODC 2ODG 6GHD 6RPR 7NDY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing TMEM240-body Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Poly-pyrimidine Tract Binding Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Low-density Lipoprotein Particle Clearance RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Commitment Complex U2AF Complex Pre-mRNA 3'-splice Site Binding Cortical Endoplasmic Reticulum Mucociliary Clearance Cadherin Binding Spindle Pole Centrosome RNA Splicing Regulation Of MRNA Metabolic Process Random Inactivation Of X Chromosome Prp19 Complex C2H2 Zinc Finger Domain Binding Axonemal Dynein Complex U2-type Prespliceosome Oocyte Development Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sperm Flagellum Assembly Positive Regulation Of Protein Export From Nucleus Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulatory NcRNA-mediated Heterochromatin Formation MRNA Processing	Protein Binding Inward Rectifier Potassium Channel Activity Fc-gamma Receptor Signaling Pathway
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