TCF23 and FIGLA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TCF23	FIGLA
Name		transcription factor 23	folliculogenesis specific bHLH transcription factor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Developmental Process Decidualization Negative Regulation Of Muscle Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Oocyte Development
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Serum metabolite levels ( 33031748 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Acne (severe) ( 24927181 )
Interacting Genes		4 interacting genes: EMD FIGLA HNRNPK U2AF2	7 interacting genes: LHX3 LHX6 LHX8 MYF5 MYOD1 MYOG TCF23
Entrez ID		150921	344018
HPRD ID		18734	12279
Ensembl ID		ENSG00000163792	ENSG00000183733
Uniprot IDs		Q7RTU1	Q6QHK4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing TMEM240-body Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Poly-pyrimidine Tract Binding Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Low-density Lipoprotein Particle Clearance RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Commitment Complex U2AF Complex Pre-mRNA 3'-splice Site Binding Cortical Endoplasmic Reticulum Mucociliary Clearance Cadherin Binding Spindle Pole Centrosome RNA Splicing Regulation Of MRNA Metabolic Process Random Inactivation Of X Chromosome Prp19 Complex C2H2 Zinc Finger Domain Binding Axonemal Dynein Complex U2-type Prespliceosome Oocyte Development Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Sperm Flagellum Assembly Positive Regulation Of Protein Export From Nucleus Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulatory NcRNA-mediated Heterochromatin Formation MRNA Processing	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Positive Regulation Of Skeletal Muscle Fiber Development Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Protein Dimerization Activity Regulation Of Striated Muscle Tissue Development Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Cell Differentiation E-box Binding Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Myoblast Differentiation Cellular Developmental Process Regulation Of Striated Muscle Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Striated Muscle Tissue Development DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Regulation Of Myoblast Fusion Forebrain Neuron Development Cell Fate Commitment Myotube Differentiation DNA-binding Transcription Activator Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Skeletal Muscle Fiber Development Animal Organ Development Myotube Cell Development Cellular Response To Estradiol Stimulus Transcription Regulator Complex Tissue Development Regulation Of Gene Expression