ROR1 and PPM1F

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ROR1	PPM1F
Description		receptor tyrosine kinase like orphan receptor 1	protein phosphatase, Mg2+/Mn2+ dependent 1F
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Cell Surface Membrane Axon Cell Projection Receptor Complex Axon Terminus	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Signaling Receptor Activity Wnt Receptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Sensory Perception Of Sound Cell Population Proliferation Astrocyte Development Wnt Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Apoptotic Process Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Migration Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)
Interacting Genes		14 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTN PTPN6 PTPRR STYX	21 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 OGT PAK1 PRKAA1 PTK7 ROR1 ROR2 WEE2-AS1
Entrez ID		4919	9647
HPRD ID		03821	10163
Ensembl ID		ENSG00000185483	ENSG00000100034
Uniprot IDs		Q01973	B5MCT7 P49593
PDB IDs		5Z55 6BA5 6BAN 6TU9 7TNG
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Regulation Of Epithelial Cell Migration Peptidyl-threonine Dephosphorylation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Response To Auditory Stimulus Negative Regulation Of Cell Communication Myeloid Leukocyte Activation Molecular Function Activator Activity Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Neuron Projection Regeneration Regulation Of Signal Transduction Microglial Cell Activation Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Synaptic Potentiation Response To Mechanical Stimulus Dendrite Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Protein Localization	Protein Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB3:ERBB2 Complex Wound Healing ERBB2 Signaling Pathway Protein Serine Kinase Activity Receptor Complex Neuregulin Receptor Activity Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Response To Epidermal Growth Factor Regulation Of Catalytic Activity Protein Phosphorylation Cell Surface Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Glial Cell Development Regulation Of Protein Localization Basal Plasma Membrane Phosphorylation Cell Death Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Insulin Receptor Signaling Pathway Axon Response To Wounding ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Migration Regulation Of Organ Growth
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