ROR1 and PPM1B

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		ROR1	PPM1B
Description		receptor tyrosine kinase like orphan receptor 1	protein phosphatase, Mg2+/Mn2+ dependent 1B
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Cell Surface Membrane Axon Cell Projection Receptor Complex Axon Terminus	Nucleus Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Signaling Receptor Activity Wnt Receptor Activity	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Sensory Perception Of Sound Cell Population Proliferation Astrocyte Development Wnt Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2	ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		14 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTN PTPN6 PTPRR STYX	21 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2
Entrez ID		4919	5495
HPRD ID		03821	04796
Ensembl ID		ENSG00000185483	ENSG00000138032
Uniprot IDs		Q01973	O75688
PDB IDs		5Z55 6BA5 6BAN 6TU9 7TNG	2P8E
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Protein Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Regulation Of Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Regulation Of Epithelial Cell Migration Peptidyl-threonine Dephosphorylation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Response To Auditory Stimulus Negative Regulation Of Cell Communication Myeloid Leukocyte Activation Molecular Function Activator Activity Regulation Of JNK Cascade Positive Regulation Of Chemotaxis Neuron Projection Regeneration Regulation Of Signal Transduction Microglial Cell Activation Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Synaptic Potentiation Response To Mechanical Stimulus Dendrite Development Phosphate-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Protein Localization	Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity ATP Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Coreceptor Activity Transferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion ERBB2 Signaling Pathway Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Linear Polyubiquitin Binding Regulation Of Epithelial Cell Proliferation Wnt-protein Binding Phosphorylation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Histone Kinase Activity Regulation Of Cell Motility Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction IkappaB Kinase Complex Positive Regulation Of Phosphate Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction
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