CTBP2 and SOX13

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CTBP2	SOX13
Gene Name		C-terminal binding protein 2	SRY (sex determining region Y)-box 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcriptional Repressor Complex Cell Junction Synapse	Nucleus Nucleoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Regulation Of Gamma-delta T Cell Differentiation
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Prostate cancer ( 18264096)
Protein-Protein Interactions		67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750	3 interactors: CTBP2 SMAD7 YTHDC1
Entrez ID		1488	9580
HPRD ID		04016	09205
Ensembl ID		ENSG00000175029	ENSG00000143842
Uniprot IDs		P56545 Q5SQP8	B4DX26 Q9UN79
PDB IDs		2OME
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Chromatin Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pathway-restricted SMAD Protein Phosphorylation Cellular Protein Complex Localization Response To Laminar Fluid Shear Stress Negative Regulation Of Peptidyl-threonine Phosphorylation White Fat Cell Differentiation Protein Complex Localization Negative Regulation Of Epithelial To Mesenchymal Transition RNA Metabolic Process Regulation Of Activin Receptor Signaling Pathway Viral Genome Replication Gene Expression Negative Regulation Of Peptidyl-serine Phosphorylation Ventricular Septum Morphogenesis Negative Regulation Of Stem Cell Differentiation Regulation Of Membrane Depolarization Response To Fluid Shear Stress MRNA Splice Site Selection Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Adherens Junction Assembly Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Tissue Morphogenesis Artery Morphogenesis Cardiac Septum Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Muscle Tissue Morphogenesis Negative Regulation Of Ubiquitin-protein Transferase Activity Artery Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression
Tagcloud ?		acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated	c57bl cd45 committed congenic considerably defect dermatitis developmental expanded gammadelta gammadeltat17 homed inflamed intrinsic lymph migrated neonatal nodes participate protected psoriasis requirements skin spontaneous subset substrain thymus trait vgamma4
Tagcloud (Difference) ?		acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated	c57bl cd45 committed congenic considerably defect dermatitis developmental expanded gammadelta gammadeltat17 homed inflamed intrinsic lymph migrated neonatal nodes participate protected psoriasis requirements skin spontaneous subset substrain thymus trait vgamma4
Tagcloud (Intersection) ?