BICDL2 and PKP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BICDL2	PKP1
Name		BICD family like cargo adaptor 2	plakophilin 1
Structure		No pdb structure
GO Annotations	Cellular Component	None	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane Desmosome Perinuclear Region Of Cytoplasm Anchoring Junction Nuclear Stress Granule Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Small GTPase Binding	DNA Binding RNA Binding Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Vesicle Transport Along Microtubule Golgi To Secretory Granule Transport	Desmosome Assembly Desmosome Maintenance Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Transepithelial Water Transport Ameloblast Differentiation Intermediate Filament Bundle Assembly Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Protein Localization To Membrane
Pathways		None	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Diseases		None	Ectodermal dysplasia/skin fragility syndrome
GWAS		No GWAS studies recorded	Panic disorder ( 19165232 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		None recorded	1 novel interactors: AP2B1
Interacting Genes		7 interacting genes: API5 CDK17 CFTR KLC3 PKP1 RPL9 TSGA10IP	17 interacting genes: ARMC8 BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		146439	5317
HPRD ID		11237	03579
Ensembl ID		ENSG00000162069	ENSG00000081277
Uniprot IDs		A1A5D9	Q13835
PDB IDs		Not available	1XM9
GO Terms Enriched among Interactors		Transepithelial Water Transport Epithelial Fluid Transport Water Transport Fluid Transport Transepithelial Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Anion Channel Activity Desmosome Maintenance Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Intermediate Filament Binding Positive Regulation Of Cytoplasmic Translational Initiation Nuclear Stress Granule Ameloblast Differentiation Intermediate Filament Bundle Assembly Desmosome Assembly Negative Regulation Of Fibroblast Apoptotic Process Sperm Mitochondrial Sheath Assembly Amelogenesis Ciliary Rootlet ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Fibroblast Apoptotic Process	Cornified Envelope Desmosome Intermediate Filament Keratin Filament Binding Ficolin-1-rich Granule Membrane Intermediate Filament Organization Scaffold Protein Binding Desmosome Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Cytoskeleton Epidermis Development Anchoring Junction Cell-cell Junction Organization