CMTM4 and TTPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CMTM4	TTPA
Description		CKLF like MARVEL transmembrane domain containing 4	alpha tocopherol transfer protein
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Late Endosome Cytosol
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process		Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance
Pathways			Vitamin E transport
Drugs
Diseases			Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS			Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)
Interacting Genes		20 interacting genes: APOA4 APPL1 COQ8A DAPK1 DGCR6L DIABLO HSBP1L1 MIDN MRPL2 PBX3 PTPN9 SMG9 SNX1 SPG21 SSX3 STAR TBRG4 TCEA2 TTPA ZFYVE21	46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52
Entrez ID		146223	7274
HPRD ID		07435	02685
Ensembl ID		ENSG00000183723	ENSG00000137561
Uniprot IDs		Q8IZR5	P49638
PDB IDs			1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux
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