LAYN and GIMAP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAYN	GIMAP5
Description		layilin	GTPase, IMAP family member 5
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Focal Adhesion Cell Surface Membrane	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process
Pathways
Drugs		Hyaluronic acid
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Fish- and plant-related diet ( 32066663) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		7 interacting genes: BCL2L13 DEFB121 GIMAP5 IGFBP5 MFSD11 PLPP6 RHOU	68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27
Entrez ID		143903	55340
HPRD ID		17299	16280
Ensembl ID		ENSG00000204381	ENSG00000196329
Uniprot IDs		B4DDS5 Q6UX15	A0A090N8P9 Q96F15
PDB IDs			6Z3E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Skeletal Muscle Hypertrophy Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process	Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly
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