CRYBB1 and ABCC8

Number of citations of the paper that reports this interaction (PMID 12941953)
40

Data Source:
HPRD (in vivo)

		CRYBB1	ABCC8
Gene Name		crystallin, beta B1	ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component		Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Structural Constituent Of Eye Lens	ATP Binding Sulfonylurea Receptor Activity Potassium Ion Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding
	Biological Process	Visual Perception	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Potassium Ion Transport Signal Transduction Synaptic Transmission Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways			Inwardly rectifying K+ channels ABC-family proteins mediated transport Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels
Drugs			Adenosine triphosphate Glimepiride Chlorpropamide Nateglinide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glycodiazine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ABCC8 CRYBA1 CRYBA2 CRYBA4 TERF1 TERF2IP	4 interactors: CRYBB1 ENSA KCNJ11 KCNJ8
Entrez ID		1414	6833
HPRD ID		09021	02741
Ensembl ID		ENSG00000100122	ENSG00000006071
Uniprot IDs		P53674	Q09428
PDB IDs		1OKI
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Camera-type Eye Development Eye Development Telomere Maintenance Negative Regulation Of Chromosome Organization Lens Development In Camera-type Eye Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination At Telomere Sensory Organ Development Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Visual Perception Sensory Perception Of Light Stimulus Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region DNA Replication Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair Regulation Of Microtubule Polymerization Protein Localization To Chromosome Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition	Potassium Ion Import Response To Glucose Potassium Ion Transmembrane Transport Response To Carbohydrate Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Cellular Response To Nicotine Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Protein Transport Regulation Of Secretion Response To ATP Response To Organic Substance Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Cation Channel Activity Vasodilation Response To Ischemia Response To PH Response To Testosterone Regulation Of Protein Localization Response To Nicotine Cellular Response To Alkaloid Negative Regulation Of Insulin Secretion Metal Ion Transport Response To Lipid Negative Regulation Of Peptide Secretion Response To Organic Cyclic Compound Response To Exogenous DsRNA Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Cation Transmembrane Transport Positive Regulation Of Transporter Activity Cellular Response To Glucose Stimulus Regulation Of Cellular Localization Negative Regulation Of Hormone Secretion Response To DsRNA Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Glucose Homeostasis Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Cellular Response To Carbohydrate Stimulus Neurological System Process Cation Transport Negative Regulation Of Protein Secretion
Tagcloud ?		aiims beaded bfsp1 cataract congenital cryaa cryab cryba4 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n	2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Difference) ?		aiims beaded bfsp1 cataract congenital cryaa cryab cryba4 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n	2kd antigenic antigens atp2a2 autoantibodies candidates cd8 copyright destruction encoded glucagon goal infiltrating islet islets min6 nod pancreatic pathogenesis pcsk2 peg3 producing proglucagon protected recognize reserved rights scg2 specificities
Tagcloud (Intersection) ?