CRYBB1 and ABCC8

Number of citations of the paper that reports this interaction (PubMedID 12941953)
0

Data Source:
HPRD (in vivo)

		CRYBB1	ABCC8
Description		crystallin beta B1	ATP binding cassette subfamily C member 8
Image
GO Annotations	Cellular Component		Plasma Membrane Inward Rectifying Potassium Channel Membrane Synaptic Vesicle Membrane Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma Presynaptic Membrane
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Nucleotide Binding Potassium Channel Activity Protein Binding ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity ADP Binding Transmembrane Transporter Binding Metal Ion Binding ABC-type Transporter Activity
	Biological Process	Lens Development In Camera-type Eye Visual Perception	Action Potential Intracellular Glucose Homeostasis Potassium Ion Transport Female Pregnancy Memory Visual Learning Response To PH Response To Xenobiotic Stimulus Response To Zinc Ion Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Angiogenesis Cellular Response To Nutrient Levels Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Potassium Ion Transport Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Neuromuscular Process Transmembrane Transport Negative Regulation Of Glial Cell Proliferation Glutamate Secretion, Neurotransmission Negative Regulation Of Neuroblast Migration Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Positive Regulation Of Uterine Smooth Muscle Relaxation Positive Regulation Of Tight Junction Disassembly Negative Regulation Of Blood-brain Barrier Permeability Potassium Ion Import Across Plasma Membrane
Pathways			ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypo- and hyper-glycemias
Drugs			ATP Glimepiride Chlorpropamide Nateglinide Tolazamide Repaglinide Glyburide Glipizide Gliclazide Tolbutamide Gliquidone Mitiglinide Glymidine
Diseases			Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM)
GWAS		Metabolite levels ( 23823483)	Academic attainment (English) ( 33594131) Alcohol dependence symptom count ( 29460428) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Gout ( 22179738) Mean arterial pressure ( 27618448) Metabolite levels ( 23823483) Two-hour glucose ( 34059833) Type 2 diabetes ( 29632382 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Weight ( 34074324)
Interacting Genes		10 interacting genes: ABCC8 AP1B1 CRYBA1 CRYBA2 CRYBA4 DDIT4L DRC4 EXOC5 TERF1 TERF2IP	5 interacting genes: CRYBB1 ENSA F2RL1 KCNJ11 KCNJ8
Entrez ID		1414	6833
HPRD ID		09021	02741
Ensembl ID		ENSG00000100122	ENSG00000006071
Uniprot IDs		P53674	A0A2R8Y4V0 A0A2R8Y5D8 A0A2R8YDG0 Q09428
PDB IDs		1OKI	6C3O 6C3P 7S5V 7S5X 7S5Y 7S5Z 7S60 7S61
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Visual Perception Sensory Perception Of Light Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Secretion By Cell Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Nervous System Process Sulfonylurea Receptor Activity Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Maintenance Potassium Ion-transporting ATPase Complex Positive Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of Blood-brain Barrier Permeability Glutamate Secretion, Neurotransmission Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Sensory Perception Inward Rectifying Potassium Channel Positive Regulation Of Tight Junction Disassembly Telomere Organization Negative Regulation Of DNA Metabolic Process Secretion Basolateral Protein Secretion Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization To Cilium ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Anoikis Regulation Of Establishment Of Protein Localization To Chromosome	Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Regulation Of Hormone Secretion Regulation Of Protein Secretion Response To ATP Determination Of Adult Lifespan Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Potassium Ion Import Across Plasma Membrane Vasodilation Response To Ischemia Cardiac Muscle Tissue Development Regulation Of Protein Transport Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion System Process Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Atrioventricular Node Cell Differentiation Inorganic Cation Import Across Plasma Membrane Regulation Of Transport Regulation Of Secretion By Cell Action Potential Regulation Of Secretion Proteinase-activated Receptor Activity Negative Regulation Of Protein Transport Myeloid Leukocyte Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Striated Muscle Tissue Development Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Negative Regulation Of Establishment Of Protein Localization
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