CRYBB1 and DRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRYBB1	DRC4
Description		crystallin beta B1	dynein regulatory complex subunit 4
Image
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Protein Binding Microtubule Binding Small GTPase Binding
	Biological Process	Lens Development In Camera-type Eye Visual Perception	Microtubule Cytoskeleton Organization Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Brain Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Motility Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Positive Regulation Of Protein Localization To Cilium
Pathways			Activation of SMO
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ABCC8 AP1B1 CRYBA1 CRYBA2 CRYBA4 DDIT4L DRC4 EXOC5 TERF1 TERF2IP	110 interacting genes: ARL6IP1 BCAR3 BORCS6 BYSL C1orf35 CARD10 CARD9 CBFA2T3 CCDC125 CCDC146 CCDC6 CCHCR1 CCNG1 CDC37 CDR2 CEP70 CFAP53 CINP CKS1B COG6 CPSF7 CRYBB1 CT45A1 CWF19L2 CYSRT1 DAXX DDX17 DISC1 DMAP1 EAF1 EHHADH EIF1AD ERCC1 EVI5L FAM161A FAM161B FHL2 GADD45GIP1 GCC1 GEM GOLGA2 GPRASP3 GRIPAP1 GSTA4 HEXIM2 HOMER3 HOMEZ HOXA1 HSF2BP IGFBP6 KDM1A KRT14 KRT15 KRT16 L3MBTL2 L3MBTL3 LASP1 LHX3 LMO1 LMO2 LZTS1 MAD1L1 MFAP1 MID2 MRFAP1L1 NDOR1 NKAPD1 PLK4 PNKP PNMA5 POLR1C POTEB3 PPFIA1 PRDM14 PRMT5 PRPF18 RALBP1 RBAK RINT1 RUBCN SCNM1 SKIL SORBS3 SP7 SPATA18 SPG21 STAC3 TCEA2 THAP1 TNFAIP3 TRAF2 TRAF5 TRIM41 TRIM54 TSFM TSGA10IP TXLNA TXLNB USHBP1 YES1 YJU2 ZBTB22 ZBTB26 ZBTB39 ZNF212 ZNF250 ZNF572 ZNF620 ZNF629 ZNF792
Entrez ID		1414	2622
HPRD ID		09021	05533
Ensembl ID		ENSG00000100122	ENSG00000141013
Uniprot IDs		P53674	A0A087WZT7 A0A384MR00 B7Z1U9 O95995
PDB IDs		1OKI	8J07
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Visual Perception Sensory Perception Of Light Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Secretion By Cell Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Nervous System Process Sulfonylurea Receptor Activity Positive Regulation Of Telomere Maintenance DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Maintenance Potassium Ion-transporting ATPase Complex Positive Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of Blood-brain Barrier Permeability Glutamate Secretion, Neurotransmission Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Sensory Perception Inward Rectifying Potassium Channel Positive Regulation Of Tight Junction Disassembly Telomere Organization Negative Regulation Of DNA Metabolic Process Secretion Basolateral Protein Secretion Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization To Cilium ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Anoikis Regulation Of Establishment Of Protein Localization To Chromosome	Identical Protein Binding Protein Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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