ZFP28 and HMOX2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZFP28	HMOX2
Gene Name		ZFP28 zinc finger protein	heme oxygenase (decycling) 2
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Gene Ontology Annotations	Cellular Component	Nucleus	Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways		Generic Transcription Pathway	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		5 interactors: C8orf33 HMOX2 KDM1A PPP2CB PRKRA	32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		140612	3163
HPRD ID		15725	00783
Ensembl ID		ENSG00000196867	ENSG00000103415
Uniprot IDs		Q8NHY6	I3L430 P30519
PDB IDs		2EM2 2EM3 2EM4 2EMJ 2EMK 2EML 2EN9 2ENH 2EOH 2EP0 2EPX 2EPZ 2YTM	2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Response To Oxidative Stress Regulation Of Primitive Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stress Heme Oxidation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Heme Catabolic Process Outer Ear Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Hormone Biosynthetic Process Production Of SiRNA Involved In RNA Interference Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator RNA Interference Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Middle Ear Morphogenesis Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hormone Metabolic Process Histone Lysine Demethylation Regulation Of Signal Transduction Histone Demethylation Regulation Of Erythrocyte Differentiation Heme Metabolic Process Cellular Response To DsRNA Protein Demethylation Posttranscriptional Gene Silencing Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Binding Regulation Of Signaling Porphyrin-containing Compound Metabolic Process Cellular Protein Modification Process Regulation Of Histone Methylation Positive Regulation Of Neural Precursor Cell Proliferation Pituitary Gland Development Negative Regulation Of Protein Binding	Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation
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