ZFP28 and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ZFP28	HMOX2
Description		ZFP28 zinc finger protein	heme oxygenase 2
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GO Annotations	Cellular Component	Nucleus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process
Pathways		Generic Transcription Pathway	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1
Drugs			NADH Stannsoporfin
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Erectile dysfunction ( 30583798)
Interacting Genes		5 interacting genes: C8orf33 HMOX2 KDM1A PPP2CB PRKRA	67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746
Entrez ID		140612	3163
HPRD ID		15725	00783
Ensembl ID		ENSG00000196867	ENSG00000103415
Uniprot IDs		Q8NHY6	A0A087WT44 B3KSE0 P30519
PDB IDs		2EM2 2EM3 2EM4 2EMJ 2EMK 2EML 2EN9 2ENH 2EOH 2EP0 2EPX 2EPZ 2YTM	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?		Response To Antibiotic Response To Oxidative Stress Heme Oxidation Heme Oxygenase (decyclizing) Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Heme Catabolic Process Regulation Of Neurofibrillary Tangle Assembly RISC-loading Complex RISC Complex Assembly SiRNA Processing Pre-miRNA Binding Outer Ear Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway Histone H3K9 Demethylase Activity Response To Fungicide MRF Binding Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein Demethylase Activity Porphyrin-containing Compound Catabolic Process SiRNA Binding Positive Regulation Of Cell Size	Membrane Protein Binding
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