AMER1 and FBXW11

Number of citations of the paper that reports this interaction (PMID 17510365)
102

Data Source:
BioGRID (affinity chromatography technology, pull down)

		AMER1	FBXW11
Gene Name		APC membrane recruitment protein 1	F-box and WD repeat domain containing 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Beta-catenin Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Wnt Signaling Pathway Bone Development Adipose Tissue Development Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Differentiation Involved In Kidney Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Antigen processing: Ubiquitination & Proteasome degradation Activation of NF-kappaB in B cells G2/M Transition Class I MHC mediated antigen processing & presentation Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Adaptive Immune System
Drugs
Diseases
GWAS			Height ( 20881960 23563607)
Protein-Protein Interactions		5 interactors: AXIN1 BTRC CTNNB1 FBXW11 KEAP1	14 interactors: AMER1 BHLHE40 BTRC CDC25A CUL1 GLI2 IFNAR1 KDR NFKB1 NFKBIA PRLR TRIM21 UBE2D3 WEE1
Entrez ID		139285	23291
HPRD ID		06565	07294
Ensembl ID		ENSG00000184675	ENSG00000072803
Uniprot IDs		Q5JTC6	B4DH70 Q9UKB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Polyubiquitination Embryonic Skeletal Joint Morphogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Embryonic Skeletal Joint Development Positive Regulation Of Circadian Rhythm Dorsal/ventral Axis Specification Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity In Utero Embryonic Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Intracellular Signal Transduction Canonical Wnt Signaling Pathway	Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Stimulus Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity G2/M Transition Of Mitotic Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Monoubiquitination Response To Organic Substance Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction Positive Regulation Of Type I Interferon Production Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Cell Cycle Phase Transition Response To Abiotic Stimulus Mammary Gland Epithelium Development Signaling Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Cell Communication Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Negative Regulation Of Gene Expression Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Biosynthetic Process Innate Immune Response Regulation Of Cellular Process Activation Of Innate Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Immune System Process Protein Destabilization G1/S Transition Of Mitotic Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Mammary Gland Development Protein Polyubiquitination Circadian Rhythm Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Innate Immune Response
Tagcloud ?			adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Difference) ?			adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized gef guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 rapgef2 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Intersection) ?