PTRH1 and ANKRD28

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTRH1	ANKRD28
Description		peptidyl-tRNA hydrolase 1 homolog	ankyrin repeat domain 28
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Serine/threonine Phosphatase Complex Lamellipodium Cell Projection
	Molecular Function	TRNA Binding RNA Binding Peptidyl-tRNA Hydrolase Activity Protein Binding Hydrolase Activity	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Rescue Of Stalled Ribosome	Positive Regulation Of Focal Adhesion Assembly
Pathways			Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: ANKRD28 FAM9B LCN2 PICK1 PRNP	34 interacting genes: ABCF2 AGPAT2 ANK2 ANKRD26 ANKRD50 BCL3 BRCA1 CCDC187 CD164 CSNK2B EEF1G EHMT2 EIF3D GADD45GIP1 HNRNPK HNRNPR INCA1 KCNV2 MYOM1 NOTCH2 NOTCH3 PIBF1 PTRH1 RNF11 TGM2 TGS1 THAP7 TMIE TNKS TNKS2 TTN UACA YTHDC1 ZNF512B
Entrez ID		138428	23243
HPRD ID		12936	10651
Ensembl ID		ENSG00000187024	ENSG00000206560
Uniprot IDs		C9J7Z1 Q86Y79	O15084
PDB IDs
Enriched GO Terms of Interacting Partners?		Dendritic Spine Maintenance Long-term Memory Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Cellular Response To Amyloid-beta Positive Regulation Of Neuron Apoptotic Process Response To Amyloid-beta Cellular Component Maintenance Positive Regulation Of Hippocampal Neuron Apoptotic Process Type 8 Metabotropic Glutamate Receptor Binding Positive Regulation Of Iron Ion Import Across Plasma Membrane Protease Binding Enterobactin Binding Memory Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Siderophore Transport Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Type 5 Metabotropic Glutamate Receptor Binding Membrane Curvature Sensor Activity Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Response To Mycotoxin Regulation Of Synaptic Plasticity Negative Regulation Of Dendritic Spine Maintenance Cupric Ion Binding Regulation Of Iron Ion Transport Response To Blue Light Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cellular Component Organization Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis ATP-dependent Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Regulation Of Neuron Apoptotic Process Cellular Response To Nutrient Levels Postsynaptic Density Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Actin Nucleation Learning Or Memory Cellular Response To X-ray Positive Regulation Of Cellular Component Organization Response To Xenobiotic Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Response To Fructose	M Band Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomere Capping Glomerular Capillary Formation Enzyme Binding Marginal Zone B Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Formation Cellular Response To Cocaine Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Protein Kinase A Signaling NAD+-protein-glutamate ADP-ribosyltransferase Activity Random Inactivation Of X Chromosome NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Capping C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Kinase Regulator Activity Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Poly-ADP-ribosylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Receptor Signaling Pathway Via STAT Mature B Cell Differentiation Involved In Immune Response Protein Localization To T-tubule Nucleoplasm Bcl3-Bcl10 Complex Mature B Cell Differentiation Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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