COX7C and MAGEA2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		COX7C	MAGEA2
Name		cytochrome c oxidase subunit 7C	MAGE family member A2
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus PML Body
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration	Negative Regulation Of Transcription By RNA Polymerase II Protein Catabolic Process Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction By P53 Class Mediator Cellular Senescence Negative Regulation Of Protein Acetylation
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	None
Drugs		Cholic Acid N-Formylmethionine	None
GWAS		Blood trace element (Cu levels) ( 23720494 ) Uterine fibroid size (maximum dimension) ( 30196971 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: ETFA MEF2C	1 novel interactors: IRAK1
Interacting Genes		3 interacting genes: CIDEB MAGEA2 MAGEA2B	21 interacting genes: ACSM1 ANKRD45 BEX1 BEX2 CCDC185 CEP57 COQ4 COX7C DYNLRB1 MBD3 MDM2 NTAQ1 P4HA3 PHKG2 POLL PSMC1 SEPTIN5 SMARCD1 TNIP3 TP53 TRIM28
Entrez ID		1350	4101
HPRD ID		04800	02165
Ensembl ID		ENSG00000127184	ENSG00000268606
Uniprot IDs		P15954	P43356
PDB IDs		5Z62	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Histone Deacetylase Binding Positive Regulation Of Ubiquitin-protein Transferase Activity DNA-binding Transcription Factor Binding Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Cellular Senescence Negative Regulation Of Post-translational Protein Modification Sinoatrial Valve Morphogenesis Electron Transfer Flavoprotein Complex Signal Transduction By P53 Class Mediator Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction PML Body Muscle Cell Fate Determination Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification Glomerulus Morphogenesis Regulation Of Synaptic Activity Regulation Of Protein Ubiquitination Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis AMPA Selective Glutamate Receptor Signaling Pathway Lipid Droplet Fusion Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Regulation Of Post-translational Protein Modification Positive Regulation Of Behavioral Fear Response Positive Regulation Of Fear Response Cardiac Ventricle Formation Regulation Of Germinal Center Formation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Ubiquitin Protein Ligase Binding Cellular Response To Parathyroid Hormone Stimulus Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Skeletal Muscle Cell Differentiation Cellular Response To Antibiotic Cardiac Chamber Formation Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Myeloid Cell Apoptotic Process Germinal Center Formation Regulation Of Behavioral Fear Response Secondary Heart Field Specification Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Catalytic Activity Negative Regulation Of Vascular Endothelial Cell Proliferation	Response To Actinomycin D Cellular Response To Actinomycin D Cellular Response To UV-C Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Antibiotic Response To UV-C Protein-containing Complex SUMO Transferase Activity