ADM and MME

Number of citations of the paper that reports this interaction (PubMedID 8687431)
0

Data Source:
HPRD (in vitro)

		ADM	MME
Description		adrenomedullin	membrane metalloendopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Lumen	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Signaling Receptor Binding Hormone Activity Adrenomedullin Receptor Binding Receptor Ligand Activity	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Vasculogenesis Neural Tube Closure Response To Yeast G Protein-coupled Receptor Internalization Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Regulation Of Urine Volume Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Developmental Growth Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Branching Involved In Labyrinthine Layer Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Vascular Associated Smooth Muscle Cell Development Calcitonin Family Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Positive Regulation Of Progesterone Biosynthetic Process Positive Regulation Of Vasculogenesis	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs			Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases
GWAS		Birth weight ( 31043758) Blood pressure ( 21909110) Blood protein levels in cardiovascular risk ( 28369058) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115 27618452 27841878) HDL cholesterol ( 20686565) Neuroticism ( 27089181) Pulse pressure ( 27841878) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115 27618452 27841878) Total cholesterol levels ( 33339817)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		6 interacting genes: CALCRL CFH DCLK3 EDN1 MME SNCA	20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP
Entrez ID		133	4311
HPRD ID		00061	00392
Ensembl ID		ENSG00000148926	ENSG00000196549
Uniprot IDs		P35318	P08473 Q3KQS6
PDB IDs		2FLY 2L7S 4RWF 5V6Y 6UUN 6UUS 6V2E 7VV0	1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?		Response To Interleukin-1 Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Endothelin B Receptor Binding Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Endothelin A Receptor Binding Response To Prostaglandin F Modulation Of Chemical Synaptic Transmission Regulation Of Ketone Metabolic Process Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Response To Peptide Cellular Response To Human Chorionic Gonadotropin Stimulus Response To Cytokine Rough Endoplasmic Reticulum Lumen Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Rhythmic Excitation Rhythmic Synaptic Transmission Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Fatty Acid Metabolic Process Synaptic Vesicle Oligopeptidase Activity Substance P Catabolic Process Positive Regulation Of Synaptic Transmission Creatinine Metabolic Process Neuropeptide Processing Response To Desipramine Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Transporter Regulator Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Chaperone-mediated Autophagy Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Receptor Activity Cellular Response To Sucrose Stimulus Maternal Process Involved In Parturition Vein Smooth Muscle Contraction	Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex
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