ADM and DCLK3

Number of citations of the paper that reports this interaction (PubMedID 23247088)
31

Data Source:
BioGRID (pull down)

		ADM	DCLK3
Description		adrenomedullin	doublecortin like kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Lumen	Nucleus Cytoplasm
	Molecular Function	Signaling Receptor Binding Hormone Activity Adrenomedullin Receptor Binding Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Vasculogenesis Neural Tube Closure Response To Yeast G Protein-coupled Receptor Internalization Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Regulation Of Urine Volume Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Developmental Growth Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Branching Involved In Labyrinthine Layer Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Vascular Associated Smooth Muscle Cell Development Calcitonin Family Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Positive Regulation Of Progesterone Biosynthetic Process Positive Regulation Of Vasculogenesis	Protein Localization To Nucleus
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Fostamatinib
Diseases
GWAS		Birth weight ( 31043758) Blood pressure ( 21909110) Blood protein levels in cardiovascular risk ( 28369058) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115 27618452 27841878) HDL cholesterol ( 20686565) Neuroticism ( 27089181) Pulse pressure ( 27841878) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115 27618452 27841878) Total cholesterol levels ( 33339817)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Chronotype ( 30696823) Morning person ( 30696823) Schizophrenia ( 28991256) Takayasu arteritis ( 25604533) White matter hyperintensity volume ( 32062564)
Interacting Genes		6 interacting genes: CALCRL CFH DCLK3 EDN1 MME SNCA	2 interacting genes: ADM RAMP1
Entrez ID		133	85443
HPRD ID		00061	19338
Ensembl ID		ENSG00000148926	ENSG00000163673
Uniprot IDs		P35318	A0A1B0GTZ4 Q9C098
PDB IDs		2FLY 2L7S 4RWF 5V6Y 6UUN 6UUS 6V2E 7VV0
Enriched GO Terms of Interacting Partners?		Response To Interleukin-1 Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Endothelin B Receptor Binding Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Endothelin A Receptor Binding Response To Prostaglandin F Modulation Of Chemical Synaptic Transmission Regulation Of Ketone Metabolic Process Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Response To Peptide Cellular Response To Human Chorionic Gonadotropin Stimulus Response To Cytokine Rough Endoplasmic Reticulum Lumen Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Rhythmic Excitation Rhythmic Synaptic Transmission Response To Type II Interferon Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Fatty Acid Metabolic Process Synaptic Vesicle Oligopeptidase Activity Substance P Catabolic Process Positive Regulation Of Synaptic Transmission Creatinine Metabolic Process Neuropeptide Processing Response To Desipramine Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Transporter Regulator Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Chaperone-mediated Autophagy Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Receptor Activity Cellular Response To Sucrose Stimulus Maternal Process Involved In Parturition Vein Smooth Muscle Contraction	Calcitonin Family Receptor Signaling Pathway Receptor Internalization Adrenomedullin Receptor Binding Positive Regulation Of Progesterone Biosynthetic Process Calcitonin Gene-related Peptide Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis CGRP Receptor Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Progesterone Biosynthetic Process Amylin Receptor 1 Signaling Pathway Positive Regulation Of Protein Glycosylation Amylin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Adrenomedullin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Regulation Of Protein Glycosylation Positive Regulation Of Hormone Biosynthetic Process Vascular Associated Smooth Muscle Cell Development Endocytosis Antifungal Humoral Response Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Vasculogenesis G Protein-coupled Receptor Internalization Negative Regulation Of Vasoconstriction Response To Yeast Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Urine Volume Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Hormone Biosynthetic Process Import Into Cell Regulation Of Ketone Biosynthetic Process Positive Regulation Of Heart Rate G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Heart Contraction Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Permeability Defense Response To Fungus Coreceptor Activity Response To Fungus Antibacterial Humoral Response Vasculogenesis
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