C1orf216 and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1orf216	TRIM72
Description		chromosome 1 open reading frame 216	tripartite motif containing 72
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sarcolemma
	Molecular Function	Protein Binding	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways			Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS
Interacting Genes		71 interacting genes: ABI2 AIMP2 AMOT BORCS6 CCDC136 CCDC158 CCDC197 CDR2 CDR2L CENPH CEP170P1 CEP55 CMC2 DES DMAP1 EIF3F EXOC5 FSD2 GGA1 HAP1 HAUS8 IFT20 KLHL20 KRT13 KRT15 KRT16 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT38 KRT39 KRT40 KRT75 KRT76 LRRC61 MAGEA6 MDFI MED4 MIS18A MLPH MRFAP1L1 MTUS2 MYRIP NECAB2 NMI NRBF2 NUP62 ODAD1 PKNOX2 PPP1R16A PSMC6 RALBP1 SERTAD3 SNW1 SYCE1L THAP1 TLE5 TMCO5A TPM1 TPM3 TRAF1 TRIM54 TRIM72 USHBP1 VPS52 WASHC1 ZDHHC17 ZNF620	19 interacting genes: ABI2 C1orf216 GSK3B INSR IRS1 MED21 MZT1 NMI RAC1 RIPK1 SMARCD1 TCF12 TRIM32 UBE2D1 UBE2H UBE2I UBE2N VSIG4 ZNF655
Entrez ID		127703	493829
HPRD ID		08798	17412
Ensembl ID		ENSG00000142686	ENSG00000177238
Uniprot IDs		Q8TAB5	Q6ZMU5
PDB IDs			3KB5 7XT2 7Y4S
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Supramolecular Fiber Organization Structural Molecule Activity Cytoskeleton Cytoskeleton Organization Epithelial Cell Differentiation Morphogenesis Of An Epithelium Tissue Morphogenesis Protein Binding Organelle Organization Anatomical Structure Morphogenesis Exocyst Intermediate Filament Cytoskeleton Structural Constituent Of Cytoskeleton Identical Protein Binding Cytosol Muscle Thin Filament Tropomyosin Myosin Binding Small GTPase Binding Epidermis Development Cell Differentiation Actin Filament Post-Golgi Vesicle-mediated Transport Actin Cytoskeleton	Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Insulin Receptor Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Glycogen Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Regulation Of Neuron Differentiation Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Catabolic Process Insulin Receptor Signaling Pathway Signaling Adaptor Activity TOR Signaling Regulation Of Metabolic Process Regulation Of Cell Projection Assembly Negative Regulation Of TOR Signaling Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of RNA Biosynthetic Process Insulin-like Growth Factor Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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