C1orf216 and NRBF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		C1orf216	NRBF2
Description		chromosome 1 open reading frame 216	nuclear receptor binding factor 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Autophagy Response To Endoplasmic Reticulum Stress
Pathways
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737) Fasting glucose ( 34059833) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular telangiectasia type 2 ( 33654266) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 24026423) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell count ( 32888494) Schizophrenia ( 30285260 28991256) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		71 interacting genes: ABI2 AIMP2 AMOT BORCS6 CCDC136 CCDC158 CCDC197 CDR2 CDR2L CENPH CEP170P1 CEP55 CMC2 DES DMAP1 EIF3F EXOC5 FSD2 GGA1 HAP1 HAUS8 IFT20 KLHL20 KRT13 KRT15 KRT16 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT38 KRT39 KRT40 KRT75 KRT76 LRRC61 MAGEA6 MDFI MED4 MIS18A MLPH MRFAP1L1 MTUS2 MYRIP NECAB2 NMI NRBF2 NUP62 ODAD1 PKNOX2 PPP1R16A PSMC6 RALBP1 SERTAD3 SNW1 SYCE1L THAP1 TLE5 TMCO5A TPM1 TPM3 TRAF1 TRIM54 TRIM72 USHBP1 VPS52 WASHC1 ZDHHC17 ZNF620	15 interacting genes: C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PPARA PRKAA2 RARA RHOU RPTOR RXRA SHANK3 THRB TSC1
Entrez ID		127703	29982
HPRD ID		08798	11401
Ensembl ID		ENSG00000142686	ENSG00000148572
Uniprot IDs		Q8TAB5	Q96F24
PDB IDs			4ZEY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Supramolecular Fiber Organization Structural Molecule Activity Cytoskeleton Cytoskeleton Organization Epithelial Cell Differentiation Morphogenesis Of An Epithelium Tissue Morphogenesis Protein Binding Organelle Organization Anatomical Structure Morphogenesis Exocyst Intermediate Filament Cytoskeleton Structural Constituent Of Cytoskeleton Identical Protein Binding Cytosol Muscle Thin Filament Tropomyosin Myosin Binding Small GTPase Binding Epidermis Development Cell Differentiation Actin Filament Post-Golgi Vesicle-mediated Transport Actin Cytoskeleton	Nuclear Receptor Activity Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Cell Size Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATP Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Monosaccharide Hormone-mediated Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Response To Carbohydrate Negative Regulation Of Hepatocyte Apoptotic Process Transcription Coactivator Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Regulation Of Glycolytic Process Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Intracellular Signal Transduction Cellular Response To Starvation MRNA Transcription TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus Response To Starvation Sequence-specific DNA Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Chromatin Binding Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Purine Nucleotide Metabolic Process
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