TNFAIP8L1 and MED4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFAIP8L1	MED4
Description		TNF alpha induced protein 8 like 1	mediator complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of TOR Signaling Regulation Of Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PI Metabolism	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		13 interacting genes: ANKRD36B APP CAVIN1 DVL3 EVI5 MAP3K5 MED4 PLEKHF2 PSME3 RPL9 SNRPA STAC3 ZRSR2	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CEBPA CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 ITSN1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TNFAIP8L1 USHBP1 WDTC1 WWP2
Entrez ID		126282	29079
HPRD ID		11314	16145
Ensembl ID		ENSG00000185361	ENSG00000136146
Uniprot IDs		Q8WVP5	Q9NPJ6
PDB IDs			7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Positive Regulation Of JNK Cascade	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex Kinetochore Centrosome Regulation Of DNA-templated Transcription Initiation Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Nucleosome Disassembly Regulation Of Embryonic Development
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