ACER1 and MPP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACER1	MPP1
Description		alkaline ceramidase 1	MAGUK p55 scaffold protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite Cell Projection
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Metal Ion Binding	GMP Kinase Activity Signaling Receptor Binding Protein Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Epidermis Development Response To Alkaline PH Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Cell Differentiation Keratinocyte Differentiation Sphingosine Biosynthetic Process Ceramide Catabolic Process Sebaceous Gland Development Cellular Response To Calcium Ion	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis
Pathways		Sphingolipid catabolism	Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715)	Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)
Interacting Genes		1 interacting genes: MPP1	46 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID DERL2 DGAT2L6 DLG4 DNPEP ERBIN FXR2 GADD45A GPRASP3 GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OGT OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639
Entrez ID		125981	4354
HPRD ID		12496	02370
Ensembl ID		ENSG00000167769	ENSG00000130830
Uniprot IDs		Q8TDN7	B4E325 Q00013
PDB IDs			2EJY 2EV8 3NEY
Enriched GO Terms of Interacting Partners?		GMP Kinase Activity GDP Metabolic Process Stereocilium Regulation Of Neutrophil Chemotaxis Cortical Cytoskeleton GMP Metabolic Process Regulation Of Neutrophil Migration Positive Regulation Of Activated T Cell Proliferation T Cell Costimulation Regulation Of Activated T Cell Proliferation Regulation Of Granulocyte Chemotaxis	Intracellular Signal Transduction TOR Signaling Ribosomal Protein S6 Kinase Activity N-acylsphingosine Amidohydrolase Activity
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