PSMB4 and PSMG3

Number of citations of the paper that reports this interaction (PubMedID 17189198)
0

Data Source:
BioGRID (pull down)

		PSMB4	PSMG3
Description		proteasome 20S subunit beta 4	proteasome assembly chaperone 3
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Ciliary Basal Body Extracellular Exosome	Cytosol Protein-containing Complex
	Molecular Function	Lipopolysaccharide Binding Protein Binding	Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Proteasome Assembly Chaperone-mediated Protein Complex Assembly
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Proteasome assembly Proteasome assembly
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971)	Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		37 interacting genes: AIRIM APP BCL6 CCDC57 CNOT2 CUL1 DTX2 FSD2 GABARAPL1 GCA HEMK1 HGS KANK2 KRTAP19-5 LCOR MYOZ3 OAZ1 P4HA3 PFDN5 PITX2 PKN1 PLK1 PRKCA PROP1 PRPF19 PSMB5 PSMD2 PSMG3 RUNX1 SMAD1 SOHLH1 SPG21 SYNPO2L TEKT5 TFAP2D TLE5 UBD	6 interacting genes: PSMB1 PSMB3 PSMB4 PSMB5 PSMG4 TAP2
Entrez ID		5692	84262
HPRD ID		03710	14404
Ensembl ID		ENSG00000159377	ENSG00000157778
Uniprot IDs		A0A140VK46 P28070	Q9BT73
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8QYN 8QYO 8QYS 8TM6 8UD9 8YIX 8YIY 8YIZ 9E8G 9E8O 9E8Q 9HMN	2Z5E 6JPT 8QYJ 8TM3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Transcription Corepressor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Somatotropin Secreting Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Germinal Center Formation Cytoplasm Regulation Of Programmed Cell Death Mitotic Nuclear Membrane Disassembly Negative Regulation Of Cell Cycle Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Proteasome Assembly Regulation Of Primary Metabolic Process Nuclear Membrane Disassembly Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Membrane Disassembly Collateral Sprouting Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Response To Interleukin-1 Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Proteasome Core Complex, Beta-subunit Complex Proteasome Core Complex Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent ABC-type Peptide Antigen Transporter Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Peptide Transmembrane Transporter Activity TAP Complex Peptide Antigen Transport ABC-type Peptide Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Cytosol To Endoplasmic Reticulum Transport Catabolic Process MHC Class Ib Protein Binding Extracellular Exosome MHC Protein Binding MHC Class I Peptide Loading Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Protein-containing Complex Assembly T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein-containing Complex Organization Protein Metabolic Process Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Lipopolysaccharide Binding Cytosol Antigen Processing And Presentation Of Exogenous Peptide Antigen ABC-type Transporter Activity Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Antigen
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