B3GAT3

Description		beta-1,3-glucuronyltransferase 3
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Catalytic Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		Glycosaminoglycan-protein linkage region biosynthesis Defective B3GAT3 causes JDSSDHD
Drugs		UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Appendicular lean mass ( 33097823) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: CCR2 CCR4 GPR35 HNRNPD SEC22B
Entrez ID		26229
HPRD ID		07564
Ensembl ID		ENSG00000149541
Uniprot IDs		G3V150 O94766 Q5U676
PDB IDs		1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?		Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity G Protein-coupled Receptor Activity Cytokine-mediated Signaling Pathway Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Circadian Regulation Of Translation Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Calcium-mediated Signaling Homeostasis Of Number Of Cells CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Cell Chemotaxis Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Response To Rapamycin Cell Dedifferentiation Neutrophil Clearance Regulation Of Biological Quality C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Autophagosome Assembly Inflammatory Response To Wounding Positive Regulation Of Glial Cell Migration
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