CCL3L1 and CCR3

Number of citations of the paper that reports this interaction (PMID 11449371)
12

Data Source:
HPRD (in vitro, in vivo)

		CCL3L1	CCR3
Gene Name		chemokine (C-C motif) ligand 3-like 1	chemokine (C-C motif) receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Chemokine Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Inflammatory Response Immune Response Negative Regulation Of Cell Proliferation Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CCR1 CCR3 CCR5 DPP4	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6349	1232
HPRD ID		03234	03167
Ensembl ID		ENSG00000205021	ENSG00000183625
Uniprot IDs		P16619	P51677 Q8TDP4 Q8TDP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Dendritic Cell Chemotaxis Dendritic Cell Migration Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Cellular Defense Response Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Chemotaxis Cellular Homeostasis Response To Cytokine Leukocyte Chemotaxis Cell Migration Chemical Homeostasis Cell Motility G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Response To Stress Cell Adhesion Leukocyte Migration Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Defense Response Homeostatic Process Movement Of Cell Or Subcellular Component Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Response To External Stimulus Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Organic Substance Regulation Of Monocyte Chemotaxis Immune System Process Viral Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Response To Organic Substance	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		cartilage ccl20 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		cartilage ccl20 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?