KRT74 and KRT25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT74	KRT25
Description		keratin 74	keratin 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization	Morphogenesis Of An Epithelium Cytoskeleton Organization Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cycle Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Venous thromboembolism ( 32232851)	Asthma ( 30929738 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		18 interacting genes: KRT13 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LMO4	26 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 MORN4 PPL
Entrez ID		121391	147183
HPRD ID		10504	17242
Ensembl ID		ENSG00000170484	ENSG00000204897
Uniprot IDs		Q7RTS7	Q6ZPD6 Q7Z3Z0
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Organelle Organization Cellular Developmental Process Extracellular Exosome Developmental Process Cytosol Hair Cycle Structural Constituent Of Cytoskeleton Epidermis Development Hair Follicle Morphogenesis Tissue Development Intermediate Filament Cytoskeleton Keratinization Terminal Web Ventral Spinal Cord Interneuron Differentiation Hair Cycle Process Keratinocyte Migration Spinal Cord Motor Neuron Cell Fate Specification	Keratinization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Cytosol Cornified Envelope Epidermis Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Tissue Development Peptide Cross-linking Desmosome Intermediate Filament Polymerization Protein Binding Structural Molecule Activity Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Negative Regulation Of Entry Of Bacterium Into Host Cell Response To Wounding
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