KRT74 and KRT36

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		KRT74	KRT36
Description		keratin 74	keratin 36
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization Regulation Of Keratinocyte Differentiation
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Venous thromboembolism ( 32232851)
Interacting Genes		18 interacting genes: KRT13 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LMO4	60 interacting genes: ABI2 ABI3 AIMP2 AMOT APP BCAS2 C1orf216 CCBE1 CCHCR1 CDC23 DMRT3 EXOC8 GEM GPS2 HCK HGS HOXC8 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 MAP3K1 MYOZ1 MYOZ3 PKN1 PLEKHN1 PPP1R18 PSMB1 QARS1 RESF1 RIBC1 SMURF1 TMSB4X TRAF4 TSGA10IP TTC23 TTLL10 TXLNA ZNF414 ZNF785
Entrez ID		121391	8689
HPRD ID		10504	05174
Ensembl ID		ENSG00000170484	ENSG00000126337
Uniprot IDs		Q7RTS7	O76013
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Organelle Organization Cellular Developmental Process Extracellular Exosome Developmental Process Cytosol Hair Cycle Structural Constituent Of Cytoskeleton Epidermis Development Hair Follicle Morphogenesis Tissue Development Intermediate Filament Cytoskeleton Keratinization Terminal Web Ventral Spinal Cord Interneuron Differentiation Hair Cycle Process Keratinocyte Migration Spinal Cord Motor Neuron Cell Fate Specification	Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Cytosol Protein Binding Extracellular Exosome Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope FATZ Binding Tissue Development Telethonin Binding Actin-based Cell Projection Structural Constituent Of Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex SCAR Complex Developmental Process Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation
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