KRT74 and KRT39

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT74	KRT39
Description		keratin 74	keratin 39
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Cytosol Cytoskeleton Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis Keratin Filament Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Venous thromboembolism ( 32232851)
Interacting Genes		18 interacting genes: KRT13 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LMO4	34 interacting genes: ANKS1A ARMC7 BEX2 C1orf216 CCDC196 CLCNKA FAM110A GFAP HGS IGFN1 KDM1A KLHL38 KRT1 KRT2 KRT3 KRT6B KRT74 KRT76 KRT78 KRT81 KRT83 KRT85 KRT86 LMO4 PPL PRPF18 SCNM1 SHC3 SMARCE1 TGM7 TXLNB UBASH3A VPS9D1 ZNF417
Entrez ID		121391	390792
HPRD ID		10504	13750
Ensembl ID		ENSG00000170484	ENSG00000196859
Uniprot IDs		Q7RTS7	Q6A163
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Supramolecular Fiber Organization Epithelial Cell Differentiation Tissue Morphogenesis Cytoskeleton Organization Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Organelle Organization Cellular Developmental Process Extracellular Exosome Developmental Process Cytosol Hair Cycle Structural Constituent Of Cytoskeleton Epidermis Development Hair Follicle Morphogenesis Tissue Development Intermediate Filament Cytoskeleton Keratinization Terminal Web Ventral Spinal Cord Interneuron Differentiation Hair Cycle Process Keratinocyte Migration Spinal Cord Motor Neuron Cell Fate Specification	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratinization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Peptide Cross-linking
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