OBFC1 and MVP

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		OBFC1	MVP
Gene Name		oligonucleotide/oligosaccharide-binding fold containing 1	major vault protein
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Stn1-Ten1 Complex	Nucleus Nuclear Pore Cytoplasm Cytoskeleton Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding Single-stranded Telomeric DNA Binding	Protein Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Replication	Cell Proliferation Protein Transport Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways
Drugs
Diseases
GWAS		Endothelial function traits ( 17903301) Interstitial lung disease ( 23583980) Telomere length ( 23535734 20421499 23001564) Uterine fibroids ( 21460842)
Protein-Protein Interactions		6 interactors: APP LDLRAP1 MVP TPP1 TUBGCP4 ZDHHC17	57 interactors: ADAMTSL4 AES BANP BZRAP1 C1orf94 CALCOCO2 CAMK2B CCDC36 CKAP4 CYTB DISC1 DLX2 EPHX2 ESR1 FAM154A FAM46C GIT2 GOLGA2 HP KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MKL1 NNT NOTCH2NL OBFC1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SERTAD1 SKIL SLC2A4 TCF4 TFCP2 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 VAC14 ZBTB32 ZMIZ2
Entrez ID		79991	9961
HPRD ID		14872	05475
Ensembl ID			ENSG00000013364
Uniprot IDs		Q9H668	B4DP93 Q14764
PDB IDs		4JOI 4JQF	1Y7X
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Regulation Of Protein Tyrosine Kinase Activity Neuromuscular Process Controlling Balance Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Cholesterol Metabolic Process Sterol Metabolic Process Neuromuscular Process Regulation Of Establishment Of Blood-brain Barrier Synaptic Growth At Neuromuscular Junction Regulation Of Protein Kinase Activity Regulation Of Protein Binding Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Intermembrane Transport Chemical Homeostasis Vitamin E Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Axon Choice Point Recognition Positive Regulation Of Telomerase Activity Telomere Assembly Regulation Of Protein Phosphorylation Steroid Metabolic Process Transport Neuron Remodeling Positive Regulation Of Cholesterol Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Lipid Metabolic Process Negative Regulation Of Cell Development Regulation Of Phosphorylation Negative Regulation Of Protein Autophosphorylation Alcohol Metabolic Process Peptide Catabolic Process Protein Metabolic Process Homeostatic Process Regulation Of Signaling Protein Transport Regulation Of Telomerase Activity Regulation Of Cellular Amino Acid Metabolic Process	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Cytokine RNA Metabolic Process Defense Response Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Apoptotic Process Protein Localization To Nucleus Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		aa ac ages biology cardiovascular caucasian cc cvd disequilibrium enrolled estimate etiologic genotyped hr insight intervals leukocyte linkage ltl minor polymorphisms rs3772190 rs4387287 rs9419958 similarly snps telomere terc trend	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Difference) ?		aa ac ages biology cardiovascular caucasian cc cvd disequilibrium enrolled estimate etiologic genotyped hr insight intervals leukocyte linkage ltl minor polymorphisms rs3772190 rs4387287 rs9419958 similarly snps telomere terc trend	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Intersection) ?