PLXNA4

Description		plexin A4
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Motor Neuron Axon Guidance Telencephalon Development Cranial Nerve Morphogenesis Facial Nerve Morphogenesis Facial Nerve Structural Organization Glossopharyngeal Nerve Morphogenesis Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vagus Nerve Morphogenesis Postganglionic Parasympathetic Fiber Development Branchiomotor Neuron Axon Guidance Chemorepulsion Of Branchiomotor Axon Anterior Commissure Morphogenesis Regulation Of Cell Migration Embryonic Heart Tube Development Sympathetic Nervous System Development Neuron Projection Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Semaphorin-plexin Signaling Pathway Sympathetic Neuron Axon Guidance Maintenance Of Synapse Structure
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Bipolar disorder ( 34002096 31043756) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Chronotype ( 30696823) Cognitive function ( 24684796) Concussion ( 33017352) Diastolic blood pressure ( 27841878) Economic and political preferences ( 22566634) Femur bone mineral density x serum urate levels interaction ( 34046847) Fractures (paediatric) ( 32742401) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Oleic acid (18:1n-9) levels ( 23362303) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Self-employment ( 23593239) Systolic blood pressure ( 27841878)
Interacting Genes		1 interacting genes: CLU
Entrez ID		91584
HPRD ID		10901
Ensembl ID		ENSG00000221866
Uniprot IDs		Q9HCM2
PDB IDs		4E74
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Activation Of Membrane Attack Complex Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Central Nervous System Myelin Maintenance Neurofibrillary Tangle Chromaffin Granule Regulation Of Neuronal Signal Transduction Positive Regulation Of Amyloid Fibril Formation Immune Complex Clearance Regulation Of Neurofibrillary Tangle Assembly Protein Import Spherical High-density Lipoprotein Particle Microglial Cell Proliferation Protein Carrier Chaperone Apical Dendrite Negative Regulation Of Amyloid Fibril Formation Myelin Maintenance Negative Regulation Of Release Of Cytochrome C From Mitochondria Protein Targeting To Vacuole Involved In Autophagy Regulation Of Complement-dependent Cytotoxicity Regulation Of Amyloid Fibril Formation Negative Regulation Of Complement Activation Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid-beta Clearance Regulation Of Inclusion Body Assembly Chaperone-mediated Protein Complex Assembly Regulation Of Complement Activation Release Of Cytochrome C From Mitochondria Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Amyloid-beta Clearance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Glial Cell Proliferation Microglial Cell Activation Protein Targeting To Lysosome Positive Regulation Of Amide Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Amyloid-beta Formation
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