CWC27 and FRA10AC1

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		CWC27	FRA10AC1
Gene Name		CWC27 spliceosome-associated protein homolog (S. cerevisiae)	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Nucleus
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: FRA10AC1 HMGA1	27 interactors: ADPRHL2 C21orf33 C7orf25 CCDC155 CHERP CWC27 DGCR14 EEF1D GDPD2 GLRX3 HABP4 IK LPPR4 MAP3K12 MFAP1 NKAP PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830
Entrez ID		10283	118924
HPRD ID		11541	12319
Ensembl ID		ENSG00000153015	ENSG00000148690
Uniprot IDs		D6REK3 Q6UX04	Q70Z53
PDB IDs		2HQ6
Enriched GO Terms of Interacting Partners?		Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Establishment Of Viral Latency Heterochromatin Assembly DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Heterochromatin Organization Positive Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing Regulation Of Cellular Senescence Cellular Senescence Base-excision Repair Cell Aging DNA Duplex Unwinding DNA Geometric Change DNA Catabolic Process, Endonucleolytic DNA-dependent DNA Replication Chromatin Assembly DNA Catabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Remodeling DNA Packaging Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Response To Virus DNA Replication DNA Conformation Change Nucleic Acid Phosphodiester Bond Hydrolysis Aging	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Isotype Switching To IgA Isotypes MRNA Export From Nucleus RNA Export From Nucleus Metabolic Process Intestinal Epithelial Structure Maintenance
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