SH2D1B and FCRLA

		SH2D1B	FCRLA
Description		SH2 domain containing 1B	Fc receptor like A
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GO Annotations	Cellular Component	Cytosol	Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Transmembrane Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response	Immune Response Cell Surface Receptor Signaling Pathway Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		117157	84824
HPRD ID		12248	06058
Ensembl ID		ENSG00000198574	ENSG00000132185
Uniprot IDs		O14796	Q7L513
PDB IDs		5KAZ	4HWN
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity ERBB2 Signaling Pathway Basal Plasma Membrane Leukocyte Activation Immune System Process Kinase Activity Defense Response Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Cell Activation Signal Transduction Cellular Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling External Side Of Plasma Membrane Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Immune Effector Process Cell Differentiation Positive Regulation Of Phosphorylation ERBB3:ERBB2 Complex Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Biosynthetic Process Molecular Function Activator Activity Regulation Of Cell Migration Response To Stress	Meiotic Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Ndc80 Complex Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Kinetochore Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitochondrial Outer Membrane Translocase Complex Porin Activity Pore Complex Protein Import Into Mitochondrial Matrix Protein Transmembrane Transporter Activity Positive Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Mitotic Nuclear Division Protein Localization To Mitochondrion
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